Hepatocellular carcinoma with marginal superparamagnetic iron oxide uptake on T2*-weighted magnetic resonance imaging: Histopathologic correlation

Kosei Ishigami, Tsuyoshi Tajima, nobuhiro fujita, Akihiro Nishie, Yoshiki Asayama, Daisuke Kakihara, Tomohiro Nakayama, Daisuke Okamoto, Akinobu Taketomi, Ken Shirabe, Hiroshi Honda

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose: To evaluate the characteristics of hepatocellular carcinomas (HCCs) with marginal superparamagnetic iron oxide (SPIO) uptake on T2*-weighted MRI. Materials and methods: The study group consisted of 73 patients with 83 surgically resected HCCs. Preoperative SPIO-enhanced MRI studies were retrospectively reviewed. Marginal SPIO uptake was considered positive if a rim-like or band-like low intensity area was present on SPIO-enhanced T2*-weighted images. The prevalence of marginal SPIO uptake was evaluated. Pathological specimens with hematoxylin and eosin staining and immunohistochemical staining of CD68 were reviewed in HCCs with marginal SPIO uptake and 33 HCCs without marginal SPIO uptake (control group). Results: Ten of 83 (12%) HCCs showed marginal SPIO uptake. All HCCs were hypervascular, and only one nodule showed a nodule-in-nodule appearance on imaging findings. The pathology specimens suggested possible causes of marginal SPIO uptake, including marginal macrophage infiltration in moderately or poorly differentiated HCC (n = 4), residual normal hepatic tissue at the marginal area of confluent multinodular or single nodular with extranodular growth type HCC (n = 3), and a well-differentiated HCC component in nodule-in-nodule type HCC (n = 3). Marginal macrophage infiltration was not seen in the control group. Conclusion: SPIO-enhanced MRI may be able to demonstrate marginal macrophage infiltration in HCC.

Original languageEnglish
JournalEuropean Journal of Radiology
Volume80
Issue number3
DOIs
Publication statusPublished - Dec 1 2011

Fingerprint

Hepatocellular Carcinoma
Magnetic Resonance Imaging
Macrophages
ferric oxide
Staining and Labeling
Control Groups
Hematoxylin
Eosine Yellowish-(YS)
Pathology
Liver
Growth

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Hepatocellular carcinoma with marginal superparamagnetic iron oxide uptake on T2*-weighted magnetic resonance imaging : Histopathologic correlation. / Ishigami, Kosei; Tajima, Tsuyoshi; fujita, nobuhiro; Nishie, Akihiro; Asayama, Yoshiki; Kakihara, Daisuke; Nakayama, Tomohiro; Okamoto, Daisuke; Taketomi, Akinobu; Shirabe, Ken; Honda, Hiroshi.

In: European Journal of Radiology, Vol. 80, No. 3, 01.12.2011.

Research output: Contribution to journalArticle

Ishigami, Kosei ; Tajima, Tsuyoshi ; fujita, nobuhiro ; Nishie, Akihiro ; Asayama, Yoshiki ; Kakihara, Daisuke ; Nakayama, Tomohiro ; Okamoto, Daisuke ; Taketomi, Akinobu ; Shirabe, Ken ; Honda, Hiroshi. / Hepatocellular carcinoma with marginal superparamagnetic iron oxide uptake on T2*-weighted magnetic resonance imaging : Histopathologic correlation. In: European Journal of Radiology. 2011 ; Vol. 80, No. 3.
@article{12b09809b70c4aec8678bfe4c53f4c9a,
title = "Hepatocellular carcinoma with marginal superparamagnetic iron oxide uptake on T2*-weighted magnetic resonance imaging: Histopathologic correlation",
abstract = "Purpose: To evaluate the characteristics of hepatocellular carcinomas (HCCs) with marginal superparamagnetic iron oxide (SPIO) uptake on T2*-weighted MRI. Materials and methods: The study group consisted of 73 patients with 83 surgically resected HCCs. Preoperative SPIO-enhanced MRI studies were retrospectively reviewed. Marginal SPIO uptake was considered positive if a rim-like or band-like low intensity area was present on SPIO-enhanced T2*-weighted images. The prevalence of marginal SPIO uptake was evaluated. Pathological specimens with hematoxylin and eosin staining and immunohistochemical staining of CD68 were reviewed in HCCs with marginal SPIO uptake and 33 HCCs without marginal SPIO uptake (control group). Results: Ten of 83 (12{\%}) HCCs showed marginal SPIO uptake. All HCCs were hypervascular, and only one nodule showed a nodule-in-nodule appearance on imaging findings. The pathology specimens suggested possible causes of marginal SPIO uptake, including marginal macrophage infiltration in moderately or poorly differentiated HCC (n = 4), residual normal hepatic tissue at the marginal area of confluent multinodular or single nodular with extranodular growth type HCC (n = 3), and a well-differentiated HCC component in nodule-in-nodule type HCC (n = 3). Marginal macrophage infiltration was not seen in the control group. Conclusion: SPIO-enhanced MRI may be able to demonstrate marginal macrophage infiltration in HCC.",
author = "Kosei Ishigami and Tsuyoshi Tajima and nobuhiro fujita and Akihiro Nishie and Yoshiki Asayama and Daisuke Kakihara and Tomohiro Nakayama and Daisuke Okamoto and Akinobu Taketomi and Ken Shirabe and Hiroshi Honda",
year = "2011",
month = "12",
day = "1",
doi = "10.1016/j.ejrad.2010.12.078",
language = "English",
volume = "80",
journal = "European Journal of Radiology",
issn = "0720-048X",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

TY - JOUR

T1 - Hepatocellular carcinoma with marginal superparamagnetic iron oxide uptake on T2*-weighted magnetic resonance imaging

T2 - Histopathologic correlation

AU - Ishigami, Kosei

AU - Tajima, Tsuyoshi

AU - fujita, nobuhiro

AU - Nishie, Akihiro

AU - Asayama, Yoshiki

AU - Kakihara, Daisuke

AU - Nakayama, Tomohiro

AU - Okamoto, Daisuke

AU - Taketomi, Akinobu

AU - Shirabe, Ken

AU - Honda, Hiroshi

PY - 2011/12/1

Y1 - 2011/12/1

N2 - Purpose: To evaluate the characteristics of hepatocellular carcinomas (HCCs) with marginal superparamagnetic iron oxide (SPIO) uptake on T2*-weighted MRI. Materials and methods: The study group consisted of 73 patients with 83 surgically resected HCCs. Preoperative SPIO-enhanced MRI studies were retrospectively reviewed. Marginal SPIO uptake was considered positive if a rim-like or band-like low intensity area was present on SPIO-enhanced T2*-weighted images. The prevalence of marginal SPIO uptake was evaluated. Pathological specimens with hematoxylin and eosin staining and immunohistochemical staining of CD68 were reviewed in HCCs with marginal SPIO uptake and 33 HCCs without marginal SPIO uptake (control group). Results: Ten of 83 (12%) HCCs showed marginal SPIO uptake. All HCCs were hypervascular, and only one nodule showed a nodule-in-nodule appearance on imaging findings. The pathology specimens suggested possible causes of marginal SPIO uptake, including marginal macrophage infiltration in moderately or poorly differentiated HCC (n = 4), residual normal hepatic tissue at the marginal area of confluent multinodular or single nodular with extranodular growth type HCC (n = 3), and a well-differentiated HCC component in nodule-in-nodule type HCC (n = 3). Marginal macrophage infiltration was not seen in the control group. Conclusion: SPIO-enhanced MRI may be able to demonstrate marginal macrophage infiltration in HCC.

AB - Purpose: To evaluate the characteristics of hepatocellular carcinomas (HCCs) with marginal superparamagnetic iron oxide (SPIO) uptake on T2*-weighted MRI. Materials and methods: The study group consisted of 73 patients with 83 surgically resected HCCs. Preoperative SPIO-enhanced MRI studies were retrospectively reviewed. Marginal SPIO uptake was considered positive if a rim-like or band-like low intensity area was present on SPIO-enhanced T2*-weighted images. The prevalence of marginal SPIO uptake was evaluated. Pathological specimens with hematoxylin and eosin staining and immunohistochemical staining of CD68 were reviewed in HCCs with marginal SPIO uptake and 33 HCCs without marginal SPIO uptake (control group). Results: Ten of 83 (12%) HCCs showed marginal SPIO uptake. All HCCs were hypervascular, and only one nodule showed a nodule-in-nodule appearance on imaging findings. The pathology specimens suggested possible causes of marginal SPIO uptake, including marginal macrophage infiltration in moderately or poorly differentiated HCC (n = 4), residual normal hepatic tissue at the marginal area of confluent multinodular or single nodular with extranodular growth type HCC (n = 3), and a well-differentiated HCC component in nodule-in-nodule type HCC (n = 3). Marginal macrophage infiltration was not seen in the control group. Conclusion: SPIO-enhanced MRI may be able to demonstrate marginal macrophage infiltration in HCC.

UR - http://www.scopus.com/inward/record.url?scp=80755128926&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80755128926&partnerID=8YFLogxK

U2 - 10.1016/j.ejrad.2010.12.078

DO - 10.1016/j.ejrad.2010.12.078

M3 - Article

C2 - 21288675

AN - SCOPUS:80755128926

VL - 80

JO - European Journal of Radiology

JF - European Journal of Radiology

SN - 0720-048X

IS - 3

ER -