Hepatocyte growth factor modulates motility and invasiveness of ovarian carcinomas via Ras-mediated pathway

Y. Ueoka, K. Kato, Y. Kuriaki, S. Horiuchi, Y. Terao, J. Nishida, H. Ueno, N. Wake

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Hepatocyte growth factor (HGF) is a multifunctional growth factor which has pleiotrophic biological effects on epithelial cells such as proliferation, motogenesis, invasiveness and morphogenesis. Peritoneal dissemination is critical for the progression of ovarian cancer, and our study revealed that HGF induces migration and invasion of ovarian cancer cells. We also demonstrated that HGF stimulates autophosphorylation of its receptor, followed by activation of the Ras-MAP (mitogen-activated peptide) kinase cascade. Moreover, infection of ovarian cancer cells with Ras dominant-negative adenovirus reduced the HGF-induced motogenic and invasive activities. Additionally, both MEK and PI3-kinase pathways downstream of Ras were involved in HGF-stimulated ovarian cancer cell invasiveness. (C) 2000 Cancer Research Campaign.

Original languageEnglish
Pages (from-to)891-899
Number of pages9
JournalBritish journal of cancer
Volume82
Issue number4
DOIs
Publication statusPublished - 2000

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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