Hepatocyte growth factor modulates motility and invasiveness of ovarian carcinomas via ras mediated pathway

Yousuke Ueoka, Kiyoko Kato, Norio Wake

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Hepatocyte growth factor (HGF) is a multifunctional growth factor which has pleiotrophic biological effects on epitherial cells, such as proliferation, motogenesis, invasiveness and morphogenesis. Peritoneal dissemination is critical for the progression of ovarian cancer and our study revealed that HGF induces migration and invasion of ovarian cancer cells. We also demonstrated that HGF stimulates autophosphorylation of its receptor, followed by activation of the Ras-MAP (mitogen-activated peptide) kinase cascade. Moreover, infection of ovarian cancer cells with Ras dominant-negative adenovirus reduced the HGF-induced motogenic and invasive activities. Additionally, both MEK and PI3-kinase pathways downstream of Ras was involved in HGF-stimulated ovarian cancer cell invasiveness.

Original languageEnglish
Pages (from-to)81-88
Number of pages8
JournalMolecular and Cellular Endocrinology
Volume202
Issue number1-2
DOIs
Publication statusPublished - Apr 28 2003

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Endocrinology

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