Hericium erinaceus extracts alter behavioral rhythm in mice

Shoko Furuta, Rika Kuwahara, Eri Hiraki, Koichiro Ohnuki, Shinobu Yasuo, Kuniyoshi Shimizu

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Hericium erinaceus (HE), an edible mushroom, has been used as a herbal medicine in several Asian countries since ancient times. HE has potential as a medicine for the treatment and prevention of dementia, a disorder closely linked with circadian rhythm. This study investigated the effects of the intake of HE extracts on behavioral rhythm, photosensitivity of the circadian clock, and clock gene mRNA expression in the suprachiasmatic nucleus (SCN), a central clock, in mice. Although the HE ethanol extract only affected the offset time of activity, the HE water extract advanced the sleep–wake cycle without affecting the free-running period, photosensitivity, or the clock gene mRNA expression in SCN. In addition, both extracts decreased wakefulness around end of active phase. The findings of the present study suggest that HE may serve as a functional food in the prevention and treatment of Alzheimer’s disease and delayed sleep phase syndrome.

Original languageEnglish
Pages (from-to)227-232
Number of pages6
JournalBiomedical Research (Japan)
Volume37
Issue number4
DOIs
Publication statusPublished - Jan 1 2016

Fingerprint

Suprachiasmatic Nucleus
Clocks
Circadian Rhythm Sleep Disorders
Gene Expression
Messenger RNA
Functional Food
Circadian Clocks
Photosensitivity
Wakefulness
Herbal Medicine
Agaricales
Circadian Rhythm
Dementia
Alzheimer Disease
Ethanol
Genes
Water
Bioelectric potentials
Therapeutics
Medicine

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Hericium erinaceus extracts alter behavioral rhythm in mice. / Furuta, Shoko; Kuwahara, Rika; Hiraki, Eri; Ohnuki, Koichiro; Yasuo, Shinobu; Shimizu, Kuniyoshi.

In: Biomedical Research (Japan), Vol. 37, No. 4, 01.01.2016, p. 227-232.

Research output: Contribution to journalArticle

Furuta, Shoko ; Kuwahara, Rika ; Hiraki, Eri ; Ohnuki, Koichiro ; Yasuo, Shinobu ; Shimizu, Kuniyoshi. / Hericium erinaceus extracts alter behavioral rhythm in mice. In: Biomedical Research (Japan). 2016 ; Vol. 37, No. 4. pp. 227-232.
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