Heteroatom-embedded medium-sized cycloalkynes: Concise synthesis, structural analysis, and reactions

Runyan Ni, Naoto Mitsuda, Takeru Kashiwagi, Kazunobu Igawa, Katsuhiko Tomooka

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

A variety of medium-sized cycloalkynes were efficiently synthesized by the double Nicholas reaction of cobalt complex and bis(hetero)substituted acyclic compound. The alkyne moiety within the ring has a unique bent structure and high reactivity toward cycloaddition reactions. Furthermore, preparation of multifunctionalized alkynes was achieved by embedding the cycloalkyne within a peptide chain.

Original languageEnglish
Pages (from-to)1190-1194
Number of pages5
JournalAngewandte Chemie - International Edition
Volume54
Issue number4
DOIs
Publication statusPublished - Jan 19 2015

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

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