Heteroditopic thiacalix[4]arene receptor having ester and bipyridyl moieties for ions binding with positive/negative allosteric effect

Xin Long Ni, Hang Cong, Akina Yoshizawa, Shofuir Rahman, Hirotsugu Tomiyasu, Ummey Rayhan, Xi Zeng, Takehiko Yamato

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

A novel ditopic receptor possessing two complexation sites and bearing 1,3-alternate conformation based thiacalix[4]arene was prepared. The binding behaviors with Na+, K+ and Ag+ ions have been examined by 1H NMR titration experiment in (CDCl3/CD 3CN; 10:1, v/v) solution. The job plots proves 1:1 complexation of 1,3-alternate-4 with Na+, K+ and Ag+ ions. Although the formation of heterogeneous dinuclear complexes was not clearly observed, the exclusive formation of mononuclear complexes of 1,3-alternate-4 with metal cations is of particular interest with positive/negative allosteric effect in thiacalix[4]arene family. These findings further demonstrate that preorganization, suitable conformational changes and affinity have a pronounced effect on the complexation process between the two different arms placed at the two edges of the thiacalix[4]arene cavity.

Original languageEnglish
Pages (from-to)110-115
Number of pages6
JournalJournal of Molecular Structure
Volume1046
DOIs
Publication statusPublished - 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Spectroscopy
  • Organic Chemistry
  • Inorganic Chemistry

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