TY - JOUR
T1 - Heteroditopic thiacalix[4]arene receptor having ester and bipyridyl moieties for ions binding with positive/negative allosteric effect
AU - Ni, Xin Long
AU - Cong, Hang
AU - Yoshizawa, Akina
AU - Rahman, Shofuir
AU - Tomiyasu, Hirotsugu
AU - Rayhan, Ummey
AU - Zeng, Xi
AU - Yamato, Takehiko
PY - 2013
Y1 - 2013
N2 - A novel ditopic receptor possessing two complexation sites and bearing 1,3-alternate conformation based thiacalix[4]arene was prepared. The binding behaviors with Na+, K+ and Ag+ ions have been examined by 1H NMR titration experiment in (CDCl3/CD 3CN; 10:1, v/v) solution. The job plots proves 1:1 complexation of 1,3-alternate-4 with Na+, K+ and Ag+ ions. Although the formation of heterogeneous dinuclear complexes was not clearly observed, the exclusive formation of mononuclear complexes of 1,3-alternate-4 with metal cations is of particular interest with positive/negative allosteric effect in thiacalix[4]arene family. These findings further demonstrate that preorganization, suitable conformational changes and affinity have a pronounced effect on the complexation process between the two different arms placed at the two edges of the thiacalix[4]arene cavity.
AB - A novel ditopic receptor possessing two complexation sites and bearing 1,3-alternate conformation based thiacalix[4]arene was prepared. The binding behaviors with Na+, K+ and Ag+ ions have been examined by 1H NMR titration experiment in (CDCl3/CD 3CN; 10:1, v/v) solution. The job plots proves 1:1 complexation of 1,3-alternate-4 with Na+, K+ and Ag+ ions. Although the formation of heterogeneous dinuclear complexes was not clearly observed, the exclusive formation of mononuclear complexes of 1,3-alternate-4 with metal cations is of particular interest with positive/negative allosteric effect in thiacalix[4]arene family. These findings further demonstrate that preorganization, suitable conformational changes and affinity have a pronounced effect on the complexation process between the two different arms placed at the two edges of the thiacalix[4]arene cavity.
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U2 - 10.1016/j.molstruc.2013.04.040
DO - 10.1016/j.molstruc.2013.04.040
M3 - Article
AN - SCOPUS:84878004399
VL - 1046
SP - 110
EP - 115
JO - Journal of Molecular Structure
JF - Journal of Molecular Structure
SN - 0022-2860
ER -