Heterogeneity and clinical role of thymidine phosphorylase activity in gastric cancer.

Y. Kakeji, Y. Maehara, K. Shibahara, S. Hasuda, T. Oshiro, H. Baba, S. Kohnoe, K. Sugimachi

Research output: Contribution to journalArticle

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Abstract

We examined the dThdPase activity in primary gastric cancer and metastatic lymph nodes from human subjects. The dThdPase activities were significantly higher in primary tumors than in the normal gastric wall, particularly in the center of the tumor rather than in the periphery (P<0.01). Tumors with a high dThdPase activity often had venous invasion (P<0.01). The dThdPase activities were significantly higher in metastatic lymph nodes than in the nodes without metastasis (P<0.01). The intratumoral heterogeneity of dThdPase activity was identified and cancer cells with high dThdPase activity may indicate that metastasis will likely occur.

Original languageEnglish
Pages (from-to)1213-1216
Number of pages4
JournalOncology reports
Volume6
Issue number6
Publication statusPublished - Jan 1 1999

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Thymidine Phosphorylase
Stomach Neoplasms
Neoplasms
Lymph Nodes
Neoplasm Metastasis
Stomach

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Kakeji, Y., Maehara, Y., Shibahara, K., Hasuda, S., Oshiro, T., Baba, H., ... Sugimachi, K. (1999). Heterogeneity and clinical role of thymidine phosphorylase activity in gastric cancer. Oncology reports, 6(6), 1213-1216.

Heterogeneity and clinical role of thymidine phosphorylase activity in gastric cancer. / Kakeji, Y.; Maehara, Y.; Shibahara, K.; Hasuda, S.; Oshiro, T.; Baba, H.; Kohnoe, S.; Sugimachi, K.

In: Oncology reports, Vol. 6, No. 6, 01.01.1999, p. 1213-1216.

Research output: Contribution to journalArticle

Kakeji, Y, Maehara, Y, Shibahara, K, Hasuda, S, Oshiro, T, Baba, H, Kohnoe, S & Sugimachi, K 1999, 'Heterogeneity and clinical role of thymidine phosphorylase activity in gastric cancer.', Oncology reports, vol. 6, no. 6, pp. 1213-1216.
Kakeji Y, Maehara Y, Shibahara K, Hasuda S, Oshiro T, Baba H et al. Heterogeneity and clinical role of thymidine phosphorylase activity in gastric cancer. Oncology reports. 1999 Jan 1;6(6):1213-1216.
Kakeji, Y. ; Maehara, Y. ; Shibahara, K. ; Hasuda, S. ; Oshiro, T. ; Baba, H. ; Kohnoe, S. ; Sugimachi, K. / Heterogeneity and clinical role of thymidine phosphorylase activity in gastric cancer. In: Oncology reports. 1999 ; Vol. 6, No. 6. pp. 1213-1216.
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