Heterogeneity of colorectal cancers and extraction of discriminator gene signatures for personalized prediction of prognosis

M. Miyake, Ichiro Takemasa, R. Matoba, M. Tanino, S. Niijima, M. Ikeda, H. Yamamoto, M. Sekimoto, S. Kuhara, T. Okayama, M. Monden, K. Matsubara, M. Mori

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5 Citations (Scopus)

Abstract

Dissected specimens of colorectal cancer (CRC) have been intensively studied using molecular sketches (gene signatures) to obtain a set of discriminator gene signatures for accurate prognosis prediction in individual patients. The discriminators obtained so far are not universally applicable, as the gene sets reflect the method and site of the study. In this study, we show that dissected stage II and III samples are significantly heterogeneous in molecular sketches, and are not appropriate sources for discriminator extraction unless handled individually. To search for an accurate discriminator gene set for prediction of metastases, we need to start with less heterogeneous stage II We examined 198 (92 stage II and 106 stage III) CRC dissected samples for the predictability of discriminator gene signatures by analyzing stage II alone, stage III alone, or in combination. The best predictive power of discriminator genes was obtained only when these genes were extracted and validated with stage II samples. An accurate discriminator gene set for the prediction of CRC metastases can be obtained by focusing on stage II samples.

Original languageEnglish
Pages (from-to)781-789
Number of pages9
JournalInternational journal of oncology
Volume39
Issue number4
DOIs
Publication statusPublished - Oct 1 2011
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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