Heterogeneously integrated laser-induced fluorescence detection devices: Integration of an excitation source

Toshihiro Kamei, Keiko Sumitomo, Sachiko Ito, Ryo Takigawa, Noriyuki Tsujimura, Hisayuki Kato, Takeshi Kobayashi, Ryutaro Maeda

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We have proposed and developed a fluorescence detector in which a thick SiO2/Ta 2O5 multilayer optical interference filter is monolithically integrated on a hydrogenated amorphous silicon (a-Si:H) PIN photodiode. Combined with the optical transparency of the detector's glass substrate, the annular shape of the detector will enable us to construct a module containing a detector and an excitation source. Based on a detection platform that comprises a fluorescence-collecting microlens and an annular fluorescence detector while using an external laser source, we have demonstrated single molecule DNA detection capability when combined with a polymerase chain reaction (PCR). We also describe our work towards the integration of an excitation source to fabricate a heterogeneously-integrated laser-induced fluorescence detection (LIF) device comprising a laser diode, micro-lenses and the integrated a-Si:H fluorescence detector.

Original languageEnglish
Article number06JL02
JournalJapanese Journal of Applied Physics
Volume53
Issue number6 SPEC. ISSUE
DOIs
Publication statusPublished - Jun 2014

Fingerprint

laser induced fluorescence
Fluorescence
Detectors
Lasers
detectors
excitation
fluorescence
Light interference
polymerase chain reaction
Polymerase chain reaction
Photodiodes
Amorphous silicon
Transparency
amorphous silicon
photodiodes
Light sources
Semiconductor lasers
Lenses
Multilayers
DNA

All Science Journal Classification (ASJC) codes

  • Engineering(all)
  • Physics and Astronomy(all)

Cite this

Heterogeneously integrated laser-induced fluorescence detection devices : Integration of an excitation source. / Kamei, Toshihiro; Sumitomo, Keiko; Ito, Sachiko; Takigawa, Ryo; Tsujimura, Noriyuki; Kato, Hisayuki; Kobayashi, Takeshi; Maeda, Ryutaro.

In: Japanese Journal of Applied Physics, Vol. 53, No. 6 SPEC. ISSUE, 06JL02, 06.2014.

Research output: Contribution to journalArticle

Kamei, Toshihiro ; Sumitomo, Keiko ; Ito, Sachiko ; Takigawa, Ryo ; Tsujimura, Noriyuki ; Kato, Hisayuki ; Kobayashi, Takeshi ; Maeda, Ryutaro. / Heterogeneously integrated laser-induced fluorescence detection devices : Integration of an excitation source. In: Japanese Journal of Applied Physics. 2014 ; Vol. 53, No. 6 SPEC. ISSUE.
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