TY - JOUR
T1 - High aromatase activity and overexpression of epidermal growth factor receptor in fibrolamellar hepatocellular carcinoma in a child
AU - Muramori, Katsumi
AU - Taguchi, Syouhei
AU - Taguchi, Tomoaki
AU - Kohashi, Kenichi
AU - Furuya, Keizo
AU - Tokuda, Kiriko
AU - Ishii, Eiichi
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2011/7
Y1 - 2011/7
N2 - An 11-year-old boy was admitted with a liver tumor and underwent right trisegmentectomy for a diagnosis of fibrolamellar hepatocellular carcinoma. He had suffered from bilateral gynecomastia for a year, which improved after complete resection of the tumor. The tumor cells had significant aromatase activity (8.03 pmol/g/h) and contained high levels of estradiol (82.1 pg/mL), which contributed to gynecomastia. Furthermore, overexpression of epidermal growth factor receptor was determined in the tumor cells, which suggests that antitumor strategies using epidermal growth factor receptor antagonists may be effective.
AB - An 11-year-old boy was admitted with a liver tumor and underwent right trisegmentectomy for a diagnosis of fibrolamellar hepatocellular carcinoma. He had suffered from bilateral gynecomastia for a year, which improved after complete resection of the tumor. The tumor cells had significant aromatase activity (8.03 pmol/g/h) and contained high levels of estradiol (82.1 pg/mL), which contributed to gynecomastia. Furthermore, overexpression of epidermal growth factor receptor was determined in the tumor cells, which suggests that antitumor strategies using epidermal growth factor receptor antagonists may be effective.
UR - http://www.scopus.com/inward/record.url?scp=79959818299&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79959818299&partnerID=8YFLogxK
U2 - 10.1097/MPH.0b013e3182011676
DO - 10.1097/MPH.0b013e3182011676
M3 - Article
C2 - 21552145
AN - SCOPUS:79959818299
VL - 33
SP - e195-e197
JO - Journal of Pediatric Hematology/Oncology
JF - Journal of Pediatric Hematology/Oncology
SN - 1077-4114
IS - 5
ER -