High aromatase activity and overexpression of epidermal growth factor receptor in fibrolamellar hepatocellular carcinoma in a child

Katsumi Muramori; Syouhei Taguchi; Tomoaki Taguchi; Kenichi Kohashi; Keizo Furuya; Kiriko Tokuda; Eiichi Ishii

doi:10.1097/MPH.0b013e3182011676

High aromatase activity and overexpression of epidermal growth factor receptor in fibrolamellar hepatocellular carcinoma in a child

Katsumi Muramori, Syouhei Taguchi, Tomoaki Taguchi, Kenichi Kohashi, Keizo Furuya, Kiriko Tokuda, Eiichi Ishii

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

An 11-year-old boy was admitted with a liver tumor and underwent right trisegmentectomy for a diagnosis of fibrolamellar hepatocellular carcinoma. He had suffered from bilateral gynecomastia for a year, which improved after complete resection of the tumor. The tumor cells had significant aromatase activity (8.03 pmol/g/h) and contained high levels of estradiol (82.1 pg/mL), which contributed to gynecomastia. Furthermore, overexpression of epidermal growth factor receptor was determined in the tumor cells, which suggests that antitumor strategies using epidermal growth factor receptor antagonists may be effective.

Original language	English
Pages (from-to)	e195-e197
Journal	Journal of Pediatric Hematology/Oncology
Volume	33
Issue number	5
DOIs	https://doi.org/10.1097/MPH.0b013e3182011676
Publication status	Published - Jul 2011

All Science Journal Classification (ASJC) codes

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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High aromatase activity and overexpression of epidermal growth factor receptor in fibrolamellar hepatocellular carcinoma in a child. / Muramori, Katsumi; Taguchi, Syouhei; Taguchi, Tomoaki; Kohashi, Kenichi; Furuya, Keizo; Tokuda, Kiriko; Ishii, Eiichi.

In: Journal of Pediatric Hematology/Oncology, Vol. 33, No. 5, 07.2011, p. e195-e197.

Research output: Contribution to journal › Article › peer-review

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