High b value diffusion-weighted imaging is more sensitive to white matter degeneration in Alzheimer's disease

Takashi Yoshiura, Futoshi Mihara, Atsuo Tanaka, Koji Ogomori, Yasumasa Ohyagi, Takayuki Taniwaki, Takeshi Yamada, Takao Yamasaki, Atsushi Ichimiya, Naoko Kinukawa, Yasuo Kuwabara, Hiroshi Honda

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

It has been reported that diffusion-weighted imaging (DWI) can detect white matter degeneration in the Alzheimer's disease (AD) brain. We hypothesized that imaging of the slow diffusion component using high b value DWI is more sensitive to AD-related white matter degeneration than is conventional DWI, and therefore we studied the effects of high b value on lesion-to-normal contrast and contrast-to-noise ratio (CNR). Seven AD patients and seven age-matched normal subjects were studied with full-tensor DWI at three different b values (1000, 2000, and 4000 s/mm2) without changing echo time or diffusion time, and the mean diffusivities in the parietal and occipital regions were measured. Statistical analyses revealed that use of higher b values significantly improves both lesion-to-normal contrast and CNR. We concluded that high b value DWI is more sensitive to AD-related white matter degeneration than is conventional DWI.

Original languageEnglish
Pages (from-to)413-419
Number of pages7
JournalNeuroImage
Volume20
Issue number1
DOIs
Publication statusPublished - Sep 1 2003

Fingerprint

Alzheimer Disease
Noise
Occipital Lobe
Parietal Lobe
Diffusion Tensor Imaging
White Matter
Brain

All Science Journal Classification (ASJC) codes

  • Neurology
  • Cognitive Neuroscience

Cite this

Yoshiura, T., Mihara, F., Tanaka, A., Ogomori, K., Ohyagi, Y., Taniwaki, T., ... Honda, H. (2003). High b value diffusion-weighted imaging is more sensitive to white matter degeneration in Alzheimer's disease. NeuroImage, 20(1), 413-419. https://doi.org/10.1016/S1053-8119(03)00342-2

High b value diffusion-weighted imaging is more sensitive to white matter degeneration in Alzheimer's disease. / Yoshiura, Takashi; Mihara, Futoshi; Tanaka, Atsuo; Ogomori, Koji; Ohyagi, Yasumasa; Taniwaki, Takayuki; Yamada, Takeshi; Yamasaki, Takao; Ichimiya, Atsushi; Kinukawa, Naoko; Kuwabara, Yasuo; Honda, Hiroshi.

In: NeuroImage, Vol. 20, No. 1, 01.09.2003, p. 413-419.

Research output: Contribution to journalArticle

Yoshiura, T, Mihara, F, Tanaka, A, Ogomori, K, Ohyagi, Y, Taniwaki, T, Yamada, T, Yamasaki, T, Ichimiya, A, Kinukawa, N, Kuwabara, Y & Honda, H 2003, 'High b value diffusion-weighted imaging is more sensitive to white matter degeneration in Alzheimer's disease', NeuroImage, vol. 20, no. 1, pp. 413-419. https://doi.org/10.1016/S1053-8119(03)00342-2
Yoshiura, Takashi ; Mihara, Futoshi ; Tanaka, Atsuo ; Ogomori, Koji ; Ohyagi, Yasumasa ; Taniwaki, Takayuki ; Yamada, Takeshi ; Yamasaki, Takao ; Ichimiya, Atsushi ; Kinukawa, Naoko ; Kuwabara, Yasuo ; Honda, Hiroshi. / High b value diffusion-weighted imaging is more sensitive to white matter degeneration in Alzheimer's disease. In: NeuroImage. 2003 ; Vol. 20, No. 1. pp. 413-419.
@article{39c570065247477f82aaca64d693f521,
title = "High b value diffusion-weighted imaging is more sensitive to white matter degeneration in Alzheimer's disease",
abstract = "It has been reported that diffusion-weighted imaging (DWI) can detect white matter degeneration in the Alzheimer's disease (AD) brain. We hypothesized that imaging of the slow diffusion component using high b value DWI is more sensitive to AD-related white matter degeneration than is conventional DWI, and therefore we studied the effects of high b value on lesion-to-normal contrast and contrast-to-noise ratio (CNR). Seven AD patients and seven age-matched normal subjects were studied with full-tensor DWI at three different b values (1000, 2000, and 4000 s/mm2) without changing echo time or diffusion time, and the mean diffusivities in the parietal and occipital regions were measured. Statistical analyses revealed that use of higher b values significantly improves both lesion-to-normal contrast and CNR. We concluded that high b value DWI is more sensitive to AD-related white matter degeneration than is conventional DWI.",
author = "Takashi Yoshiura and Futoshi Mihara and Atsuo Tanaka and Koji Ogomori and Yasumasa Ohyagi and Takayuki Taniwaki and Takeshi Yamada and Takao Yamasaki and Atsushi Ichimiya and Naoko Kinukawa and Yasuo Kuwabara and Hiroshi Honda",
year = "2003",
month = "9",
day = "1",
doi = "10.1016/S1053-8119(03)00342-2",
language = "English",
volume = "20",
pages = "413--419",
journal = "NeuroImage",
issn = "1053-8119",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - High b value diffusion-weighted imaging is more sensitive to white matter degeneration in Alzheimer's disease

AU - Yoshiura, Takashi

AU - Mihara, Futoshi

AU - Tanaka, Atsuo

AU - Ogomori, Koji

AU - Ohyagi, Yasumasa

AU - Taniwaki, Takayuki

AU - Yamada, Takeshi

AU - Yamasaki, Takao

AU - Ichimiya, Atsushi

AU - Kinukawa, Naoko

AU - Kuwabara, Yasuo

AU - Honda, Hiroshi

PY - 2003/9/1

Y1 - 2003/9/1

N2 - It has been reported that diffusion-weighted imaging (DWI) can detect white matter degeneration in the Alzheimer's disease (AD) brain. We hypothesized that imaging of the slow diffusion component using high b value DWI is more sensitive to AD-related white matter degeneration than is conventional DWI, and therefore we studied the effects of high b value on lesion-to-normal contrast and contrast-to-noise ratio (CNR). Seven AD patients and seven age-matched normal subjects were studied with full-tensor DWI at three different b values (1000, 2000, and 4000 s/mm2) without changing echo time or diffusion time, and the mean diffusivities in the parietal and occipital regions were measured. Statistical analyses revealed that use of higher b values significantly improves both lesion-to-normal contrast and CNR. We concluded that high b value DWI is more sensitive to AD-related white matter degeneration than is conventional DWI.

AB - It has been reported that diffusion-weighted imaging (DWI) can detect white matter degeneration in the Alzheimer's disease (AD) brain. We hypothesized that imaging of the slow diffusion component using high b value DWI is more sensitive to AD-related white matter degeneration than is conventional DWI, and therefore we studied the effects of high b value on lesion-to-normal contrast and contrast-to-noise ratio (CNR). Seven AD patients and seven age-matched normal subjects were studied with full-tensor DWI at three different b values (1000, 2000, and 4000 s/mm2) without changing echo time or diffusion time, and the mean diffusivities in the parietal and occipital regions were measured. Statistical analyses revealed that use of higher b values significantly improves both lesion-to-normal contrast and CNR. We concluded that high b value DWI is more sensitive to AD-related white matter degeneration than is conventional DWI.

UR - http://www.scopus.com/inward/record.url?scp=0141869833&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0141869833&partnerID=8YFLogxK

U2 - 10.1016/S1053-8119(03)00342-2

DO - 10.1016/S1053-8119(03)00342-2

M3 - Article

C2 - 14527601

AN - SCOPUS:0141869833

VL - 20

SP - 413

EP - 419

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

IS - 1

ER -