High-dose Chemotherapy Combined with Peripheral Blood Stem Cell Transplantation for Two Cases with Small-cell Lung Cancer

Yoichi Nakanishi, Masayuki Kawasaki, Hiroaki Matsuki, Sanae Ochiai, Jun Yatsunami, Nobuyuki Hara

Research output: Contribution to journalArticle

Abstract

Two patients with small-cell lung cancer were treated with high-dose intensification therapy combined with peripheral blood stem cell transplantation. Case 1 was a 53 year-old male, who was diagnosed as limited-stage small-cell lung cancer with superior vena cava syndrome. Case 2 was a 55 year-old male, diagnosed as extensive-stage small-cell lung cancer. Both patients achieved partial response (a greater than 90% reduction in tumor size) to conventional-dose induction chemotherapy with cisplatin, carboplatin and etoposide. Peripheral blood stem cells were collected by leukopheresis at a recovery phase of bone marrow function with mobilization by granulocyte-colony stimulating factor following an intensified chemotherapy with cisplatin and etoposide. Thereafter, they were treated with high-dose etoposide (1200 mg/m2) and carboplatin (2, 100mg/body and 3, 000mg/body) combined with peripheral blood stem cell transplantation. Recovery of bone marrow function after peripheral blood stem cell transplantation was seen on day 9 and 13, respectively, and other treatment-related side effects were slight. It is suggested that peripheral blood stem cell transplantation is useful for hematopoietic support after high-dose intensification therapy.

Original languageEnglish
Pages (from-to)349-355
Number of pages7
JournalHaigan
Volume35
Issue number3
DOIs
Publication statusPublished - Jan 1 1995

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Peripheral Blood Stem Cell Transplantation
Small Cell Lung Carcinoma
Etoposide
Drug Therapy
Carboplatin
Cisplatin
Bone Marrow
Superior Vena Cava Syndrome
Leukapheresis
Induction Chemotherapy
Granulocyte Colony-Stimulating Factor
Therapeutics
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Pulmonary and Respiratory Medicine

Cite this

High-dose Chemotherapy Combined with Peripheral Blood Stem Cell Transplantation for Two Cases with Small-cell Lung Cancer. / Nakanishi, Yoichi; Kawasaki, Masayuki; Matsuki, Hiroaki; Ochiai, Sanae; Yatsunami, Jun; Hara, Nobuyuki.

In: Haigan, Vol. 35, No. 3, 01.01.1995, p. 349-355.

Research output: Contribution to journalArticle

Nakanishi, Y, Kawasaki, M, Matsuki, H, Ochiai, S, Yatsunami, J & Hara, N 1995, 'High-dose Chemotherapy Combined with Peripheral Blood Stem Cell Transplantation for Two Cases with Small-cell Lung Cancer', Haigan, vol. 35, no. 3, pp. 349-355. https://doi.org/10.2482/haigan.35.349
Nakanishi, Yoichi ; Kawasaki, Masayuki ; Matsuki, Hiroaki ; Ochiai, Sanae ; Yatsunami, Jun ; Hara, Nobuyuki. / High-dose Chemotherapy Combined with Peripheral Blood Stem Cell Transplantation for Two Cases with Small-cell Lung Cancer. In: Haigan. 1995 ; Vol. 35, No. 3. pp. 349-355.
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