High-frequency affine mechanics and nonaffine relaxation in a model cytoskeleton

David A. Head, Emi Ikebe, Akiko Nakamasu, Peijuan Zhang, Lara Gay Villaruz, Suguru Kinoshita, Shoji Ando, Daisuke Mizuno

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

The cytoskeleton is a network of crosslinked, semiflexible filaments, and it has been suggested that it has properties of a glassy state. Here we employ optical-trap-based microrheology to apply forces to a model cytoskeleton and measure the high-bandwidth response at an anterior point. Simulating the highly nonlinear and anisotropic stress-strain propagation assuming affinity, we found that theoretical predictions for the quasistatic response of semiflexible polymers are only realized at high frequencies inaccessible to conventional rheometers. We give a theoretical basis for determining the frequency when both affinity and quasistaticity are valid, and we discuss with experimental evidence that the relaxations at lower frequencies can be characterized by the experimentally obtained nonaffinity parameter.

Original languageEnglish
Article number042711
JournalPhysical Review E - Statistical, Nonlinear, and Soft Matter Physics
Volume89
Issue number4
DOIs
Publication statusPublished - Apr 21 2014

All Science Journal Classification (ASJC) codes

  • Statistical and Nonlinear Physics
  • Statistics and Probability
  • Condensed Matter Physics

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