High-frequency affine mechanics and nonaffine relaxation in a model cytoskeleton

David A. Head, Emi Ikebe, Akiko Nakamasu, Peijuan Zhang, Lara Gay Villaruz, Suguru Kinoshita, Shoji Ando, Daisuke Mizuno

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The cytoskeleton is a network of crosslinked, semiflexible filaments, and it has been suggested that it has properties of a glassy state. Here we employ optical-trap-based microrheology to apply forces to a model cytoskeleton and measure the high-bandwidth response at an anterior point. Simulating the highly nonlinear and anisotropic stress-strain propagation assuming affinity, we found that theoretical predictions for the quasistatic response of semiflexible polymers are only realized at high frequencies inaccessible to conventional rheometers. We give a theoretical basis for determining the frequency when both affinity and quasistaticity are valid, and we discuss with experimental evidence that the relaxations at lower frequencies can be characterized by the experimentally obtained nonaffinity parameter.

Original languageEnglish
Article number042711
JournalPhysical Review E - Statistical, Nonlinear, and Soft Matter Physics
Volume89
Issue number4
DOIs
Publication statusPublished - Apr 21 2014

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Cytoskeleton
Affine transformation
Mechanics
affinity
rheometers
Filament
Trap
Low Frequency
filaments
Polymers
Bandwidth
traps
Valid
Propagation
low frequencies
bandwidth
propagation
Prediction
polymers
predictions

All Science Journal Classification (ASJC) codes

  • Statistical and Nonlinear Physics
  • Statistics and Probability
  • Condensed Matter Physics

Cite this

High-frequency affine mechanics and nonaffine relaxation in a model cytoskeleton. / Head, David A.; Ikebe, Emi; Nakamasu, Akiko; Zhang, Peijuan; Villaruz, Lara Gay; Kinoshita, Suguru; Ando, Shoji; Mizuno, Daisuke.

In: Physical Review E - Statistical, Nonlinear, and Soft Matter Physics, Vol. 89, No. 4, 042711, 21.04.2014.

Research output: Contribution to journalArticle

Head, David A. ; Ikebe, Emi ; Nakamasu, Akiko ; Zhang, Peijuan ; Villaruz, Lara Gay ; Kinoshita, Suguru ; Ando, Shoji ; Mizuno, Daisuke. / High-frequency affine mechanics and nonaffine relaxation in a model cytoskeleton. In: Physical Review E - Statistical, Nonlinear, and Soft Matter Physics. 2014 ; Vol. 89, No. 4.
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