High frequency of allergic conjunctivitis in myasthenia gravis without thymoma

Hiroyuki Murai, Manabu Osoegawa, Hirofumi Ochi, Jun Ichi Kira

Research output: Contribution to journalArticle

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Abstract

To investigate the frequency of allergic disorders in myasthenia gravis (MG) patients and characterize the features of MG associated with allergic disorders. Frequencies of past and present common allergic disorders in 160 MG patients who visited the Department of Neurology, Kyushu University Hospital from April 2000 to July 2003 and in 81 neurological normal controls were studied. Among various allergic disorders, the frequency of allergic conjunctivitis (AC) was significantly higher in MG patients (39/160, 24.4%, p corr=0.0112), especially with MG without thymoma (36/123, 29.3%, p corr=0.0016), in comparison to the controls (6/81, 7.4%). MG patients with AC showed a significantly higher rate of seronegative MG (43.6% vs. 17.4%, p=0.008) and a higher tendency of ocular MG (43.6% vs. 28.1%, p=0.071). Moreover, MG with AC had significantly lower anti-acetylcholine receptor antibody titers (median 6.8 nmol/l vs. median 23.6 nmol/l, p=0.0359) as well as a lower rate of coexisting thymoma (7.7% vs. 17.4%, p=0.016). The incidence of myasthenic crisis was also lower in MG with AC than without AC, yet the difference was not significant (7.7% vs. 15.7%). There was a significant association of AC with MG especially for ocular or seronegative MG in cases without thymoma.

Original languageEnglish
Pages (from-to)27-31
Number of pages5
JournalJournal of the Neurological Sciences
Volume225
Issue number1-2
DOIs
Publication statusPublished - Oct 15 2004

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Allergic Conjunctivitis
Thymoma
Myasthenia Gravis
Muscle Weakness
Cholinergic Receptors
Neurology

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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High frequency of allergic conjunctivitis in myasthenia gravis without thymoma. / Murai, Hiroyuki; Osoegawa, Manabu; Ochi, Hirofumi; Kira, Jun Ichi.

In: Journal of the Neurological Sciences, Vol. 225, No. 1-2, 15.10.2004, p. 27-31.

Research output: Contribution to journalArticle

Murai, Hiroyuki ; Osoegawa, Manabu ; Ochi, Hirofumi ; Kira, Jun Ichi. / High frequency of allergic conjunctivitis in myasthenia gravis without thymoma. In: Journal of the Neurological Sciences. 2004 ; Vol. 225, No. 1-2. pp. 27-31.
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