High incidence of ultraviolet-B-or chemical-carcinogen-induced skin tumours in mice lacking the xeroderma pigmentosum group A gene

Hironobu Nakane, Seiji Takeuchi, Shunsuke Yuba, Masafumi Saijo, Yoshimichi Nakatsu, Hiroaki Murai, Yoko Nakatsuru, Takatoshi Ishikawa, Seiichi Hirota, Yukihiko Kitamura, Yoko Kato, Yukio Tsunoda, Hiroko Miyauchi, Takeshi Horio, Tomoyuki Tokunaga, Tsukasa Matsunaga, Osamu Nikaido, Yoshitake Nishimune, Yoshio Okada, Kiyoji Tanaka

Research output: Contribution to journalArticle

244 Citations (Scopus)

Abstract

XERODERMA pigmentosum (XP) is an autosomal recessive disorder characterized by a high frequency of skin cancer on sun-exposed areas, and neurological complications. XP has a defect in the early step(s) of nucleotide-excision repair (NER) and consists of eight different genetic complementation groups (groups A–G and a variant)1. We established XPA (group-A XP) gene-deficient mice by gene targeting of mouse embryonic stem (ES) cells. The XPA-deficient mice showed neither obvious physical abnormalities nor pathological alterations, but were defective in NER and highly susceptible to ultraviolet-B- or 9, 10-dimethyl-l, 2-benz[a]anthra-cene-induced skin carcinogenesis. These findings provide in vivo evidence that the XPA protein protects mice from carcinogenesis initiated by ultraviolet or chemical carcinogen. The XP A -deficient mice may provide a good in vivo model to study the high incidence of skin carcinogenesis in group A XP patients.

Original languageEnglish
Pages (from-to)165-168
Number of pages4
JournalNature
Volume377
Issue number6545
DOIs
Publication statusPublished - Sep 14 1995
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General

Fingerprint Dive into the research topics of 'High incidence of ultraviolet-B-or chemical-carcinogen-induced skin tumours in mice lacking the xeroderma pigmentosum group A gene'. Together they form a unique fingerprint.

  • Cite this

    Nakane, H., Takeuchi, S., Yuba, S., Saijo, M., Nakatsu, Y., Murai, H., Nakatsuru, Y., Ishikawa, T., Hirota, S., Kitamura, Y., Kato, Y., Tsunoda, Y., Miyauchi, H., Horio, T., Tokunaga, T., Matsunaga, T., Nikaido, O., Nishimune, Y., Okada, Y., & Tanaka, K. (1995). High incidence of ultraviolet-B-or chemical-carcinogen-induced skin tumours in mice lacking the xeroderma pigmentosum group A gene. Nature, 377(6545), 165-168. https://doi.org/10.1038/377165a0