High incidence of ultraviolet-B-or chemical-carcinogen-induced skin tumours in mice lacking the xeroderma pigmentosum group A gene

Hironobu Nakane, Seiji Takeuchi, Shunsuke Yuba, Masafumi Saijo, Yoshimichi Nakatsu, Hiroaki Murai, Yoko Nakatsuru, Takatoshi Ishikawa, Seiichi Hirota, Yukihiko Kitamura, Yoko Kato, Yukio Tsunoda, Hiroko Miyauchi, Takeshi Horio, Tomoyuki Tokunaga, Tsukasa Matsunaga, Osamu Nikaido, Yoshitake Nishimune, Yoshio Okada, Kiyoji Tanaka

Research output: Contribution to journalArticle

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Abstract

XERODERMA pigmentosum (XP) is an autosomal recessive disorder characterized by a high frequency of skin cancer on sun-exposed areas, and neurological complications. XP has a defect in the early step(s) of nucleotide-excision repair (NER) and consists of eight different genetic complementation groups (groups A–G and a variant)1. We established XPA (group-A XP) gene-deficient mice by gene targeting of mouse embryonic stem (ES) cells. The XPA-deficient mice showed neither obvious physical abnormalities nor pathological alterations, but were defective in NER and highly susceptible to ultraviolet-B- or 9, 10-dimethyl-l, 2-benz[a]anthra-cene-induced skin carcinogenesis. These findings provide in vivo evidence that the XPA protein protects mice from carcinogenesis initiated by ultraviolet or chemical carcinogen. The XP A -deficient mice may provide a good in vivo model to study the high incidence of skin carcinogenesis in group A XP patients.

Original languageEnglish
Pages (from-to)165-168
Number of pages4
JournalNature
Volume377
Issue number6545
DOIs
Publication statusPublished - Sep 14 1995

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Xeroderma Pigmentosum
Carcinogens
Skin
Carcinogenesis
Incidence
DNA Repair
Genes
Neoplasms
Gene Targeting
Skin Neoplasms
Solar System
Cohort Studies
Proteins

All Science Journal Classification (ASJC) codes

  • General

Cite this

High incidence of ultraviolet-B-or chemical-carcinogen-induced skin tumours in mice lacking the xeroderma pigmentosum group A gene. / Nakane, Hironobu; Takeuchi, Seiji; Yuba, Shunsuke; Saijo, Masafumi; Nakatsu, Yoshimichi; Murai, Hiroaki; Nakatsuru, Yoko; Ishikawa, Takatoshi; Hirota, Seiichi; Kitamura, Yukihiko; Kato, Yoko; Tsunoda, Yukio; Miyauchi, Hiroko; Horio, Takeshi; Tokunaga, Tomoyuki; Matsunaga, Tsukasa; Nikaido, Osamu; Nishimune, Yoshitake; Okada, Yoshio; Tanaka, Kiyoji.

In: Nature, Vol. 377, No. 6545, 14.09.1995, p. 165-168.

Research output: Contribution to journalArticle

Nakane, H, Takeuchi, S, Yuba, S, Saijo, M, Nakatsu, Y, Murai, H, Nakatsuru, Y, Ishikawa, T, Hirota, S, Kitamura, Y, Kato, Y, Tsunoda, Y, Miyauchi, H, Horio, T, Tokunaga, T, Matsunaga, T, Nikaido, O, Nishimune, Y, Okada, Y & Tanaka, K 1995, 'High incidence of ultraviolet-B-or chemical-carcinogen-induced skin tumours in mice lacking the xeroderma pigmentosum group A gene', Nature, vol. 377, no. 6545, pp. 165-168. https://doi.org/10.1038/377165a0
Nakane, Hironobu ; Takeuchi, Seiji ; Yuba, Shunsuke ; Saijo, Masafumi ; Nakatsu, Yoshimichi ; Murai, Hiroaki ; Nakatsuru, Yoko ; Ishikawa, Takatoshi ; Hirota, Seiichi ; Kitamura, Yukihiko ; Kato, Yoko ; Tsunoda, Yukio ; Miyauchi, Hiroko ; Horio, Takeshi ; Tokunaga, Tomoyuki ; Matsunaga, Tsukasa ; Nikaido, Osamu ; Nishimune, Yoshitake ; Okada, Yoshio ; Tanaka, Kiyoji. / High incidence of ultraviolet-B-or chemical-carcinogen-induced skin tumours in mice lacking the xeroderma pigmentosum group A gene. In: Nature. 1995 ; Vol. 377, No. 6545. pp. 165-168.
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abstract = "XERODERMA pigmentosum (XP) is an autosomal recessive disorder characterized by a high frequency of skin cancer on sun-exposed areas, and neurological complications. XP has a defect in the early step(s) of nucleotide-excision repair (NER) and consists of eight different genetic complementation groups (groups A–G and a variant)1. We established XPA (group-A XP) gene-deficient mice by gene targeting of mouse embryonic stem (ES) cells. The XPA-deficient mice showed neither obvious physical abnormalities nor pathological alterations, but were defective in NER and highly susceptible to ultraviolet-B- or 9, 10-dimethyl-l, 2-benz[a]anthra-cene-induced skin carcinogenesis. These findings provide in vivo evidence that the XPA protein protects mice from carcinogenesis initiated by ultraviolet or chemical carcinogen. The XP A -deficient mice may provide a good in vivo model to study the high incidence of skin carcinogenesis in group A XP patients.",
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AU - Saijo, Masafumi

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AU - Murai, Hiroaki

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AU - Kato, Yoko

AU - Tsunoda, Yukio

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AU - Horio, Takeshi

AU - Tokunaga, Tomoyuki

AU - Matsunaga, Tsukasa

AU - Nikaido, Osamu

AU - Nishimune, Yoshitake

AU - Okada, Yoshio

AU - Tanaka, Kiyoji

PY - 1995/9/14

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N2 - XERODERMA pigmentosum (XP) is an autosomal recessive disorder characterized by a high frequency of skin cancer on sun-exposed areas, and neurological complications. XP has a defect in the early step(s) of nucleotide-excision repair (NER) and consists of eight different genetic complementation groups (groups A–G and a variant)1. We established XPA (group-A XP) gene-deficient mice by gene targeting of mouse embryonic stem (ES) cells. The XPA-deficient mice showed neither obvious physical abnormalities nor pathological alterations, but were defective in NER and highly susceptible to ultraviolet-B- or 9, 10-dimethyl-l, 2-benz[a]anthra-cene-induced skin carcinogenesis. These findings provide in vivo evidence that the XPA protein protects mice from carcinogenesis initiated by ultraviolet or chemical carcinogen. The XP A -deficient mice may provide a good in vivo model to study the high incidence of skin carcinogenesis in group A XP patients.

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