High intramuscular adipose tissue content as a precondition of sarcopenia in patients with aortic aneurysm

Yutaka Matsubara, Tadashi Furuyama, Ken Nakayama, Keiji Yoshiya, Kentaro Inoue, Koichi Morisaki, Masazumi Kume, Yoshihiko Maehara

Research output: Contribution to journalArticle

Abstract

Purpose: Sarcopenia is a major problem of the elderly. Although little is known about the cause of sarcopenia, the intramuscular adipose tissue content (IMAC) is known to be a cause of sarcopenia. The aim of this study was to investigate the significance of IMAC as a cause of sarcopenia. Methods: We evaluated patients who underwent aneurysm repair and were monitored preoperatively and 3 years postoperatively by computed tomography (CT). The skeletal muscle area and IMAC were measured on preoperative L3 CT images. The clinical characteristics and risk factors for skeletal muscle wasting were assessed. Results: Among the 155 patients, 38 (24.5%) had > 10% skeletal muscle wasting 3 years after the operation. Patients with > 10% skeletal muscle wasting had higher IMACs of the iliopsoas (− 0.31 ± 0.01 vs. −0.45 ± 0.01, P < 0.001) muscles and higher rates of cerebrovascular infarctions (7.7 vs. 23.7%, P = 0.0068), lung cancer (0 vs. 10.5%, P < 0.001), and urgent operations (0.9 vs. 10.5%, P = 0.029) and a longer postoperative fasting period (1.3 ± 0.1 vs. 3.1 ± 0.9 days, P < 0.001) than those without > 10% skeletal muscle wasting. The IMAC of the iliopsoas muscle correlated strongly with skeletal muscle wasting (P < 0.05, r = 0.70). Conclusions: A high IMAC of the iliopsoas muscle may cause sarcopenia and thus be a clinical target in disease prevention.

Original languageEnglish
Pages (from-to)1052-1059
Number of pages8
JournalSurgery today
Volume48
Issue number12
DOIs
Publication statusPublished - Dec 1 2018

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Sarcopenia
Aortic Aneurysm
Adipose Tissue
Skeletal Muscle
Tomography
Muscles
Aneurysm

All Science Journal Classification (ASJC) codes

  • Surgery

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High intramuscular adipose tissue content as a precondition of sarcopenia in patients with aortic aneurysm. / Matsubara, Yutaka; Furuyama, Tadashi; Nakayama, Ken; Yoshiya, Keiji; Inoue, Kentaro; Morisaki, Koichi; Kume, Masazumi; Maehara, Yoshihiko.

In: Surgery today, Vol. 48, No. 12, 01.12.2018, p. 1052-1059.

Research output: Contribution to journalArticle

Matsubara, Yutaka ; Furuyama, Tadashi ; Nakayama, Ken ; Yoshiya, Keiji ; Inoue, Kentaro ; Morisaki, Koichi ; Kume, Masazumi ; Maehara, Yoshihiko. / High intramuscular adipose tissue content as a precondition of sarcopenia in patients with aortic aneurysm. In: Surgery today. 2018 ; Vol. 48, No. 12. pp. 1052-1059.
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abstract = "Purpose: Sarcopenia is a major problem of the elderly. Although little is known about the cause of sarcopenia, the intramuscular adipose tissue content (IMAC) is known to be a cause of sarcopenia. The aim of this study was to investigate the significance of IMAC as a cause of sarcopenia. Methods: We evaluated patients who underwent aneurysm repair and were monitored preoperatively and 3 years postoperatively by computed tomography (CT). The skeletal muscle area and IMAC were measured on preoperative L3 CT images. The clinical characteristics and risk factors for skeletal muscle wasting were assessed. Results: Among the 155 patients, 38 (24.5{\%}) had > 10{\%} skeletal muscle wasting 3 years after the operation. Patients with > 10{\%} skeletal muscle wasting had higher IMACs of the iliopsoas (− 0.31 ± 0.01 vs. −0.45 ± 0.01, P < 0.001) muscles and higher rates of cerebrovascular infarctions (7.7 vs. 23.7{\%}, P = 0.0068), lung cancer (0 vs. 10.5{\%}, P < 0.001), and urgent operations (0.9 vs. 10.5{\%}, P = 0.029) and a longer postoperative fasting period (1.3 ± 0.1 vs. 3.1 ± 0.9 days, P < 0.001) than those without > 10{\%} skeletal muscle wasting. The IMAC of the iliopsoas muscle correlated strongly with skeletal muscle wasting (P < 0.05, r = 0.70). Conclusions: A high IMAC of the iliopsoas muscle may cause sarcopenia and thus be a clinical target in disease prevention.",
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AU - Matsubara, Yutaka

AU - Furuyama, Tadashi

AU - Nakayama, Ken

AU - Yoshiya, Keiji

AU - Inoue, Kentaro

AU - Morisaki, Koichi

AU - Kume, Masazumi

AU - Maehara, Yoshihiko

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N2 - Purpose: Sarcopenia is a major problem of the elderly. Although little is known about the cause of sarcopenia, the intramuscular adipose tissue content (IMAC) is known to be a cause of sarcopenia. The aim of this study was to investigate the significance of IMAC as a cause of sarcopenia. Methods: We evaluated patients who underwent aneurysm repair and were monitored preoperatively and 3 years postoperatively by computed tomography (CT). The skeletal muscle area and IMAC were measured on preoperative L3 CT images. The clinical characteristics and risk factors for skeletal muscle wasting were assessed. Results: Among the 155 patients, 38 (24.5%) had > 10% skeletal muscle wasting 3 years after the operation. Patients with > 10% skeletal muscle wasting had higher IMACs of the iliopsoas (− 0.31 ± 0.01 vs. −0.45 ± 0.01, P < 0.001) muscles and higher rates of cerebrovascular infarctions (7.7 vs. 23.7%, P = 0.0068), lung cancer (0 vs. 10.5%, P < 0.001), and urgent operations (0.9 vs. 10.5%, P = 0.029) and a longer postoperative fasting period (1.3 ± 0.1 vs. 3.1 ± 0.9 days, P < 0.001) than those without > 10% skeletal muscle wasting. The IMAC of the iliopsoas muscle correlated strongly with skeletal muscle wasting (P < 0.05, r = 0.70). Conclusions: A high IMAC of the iliopsoas muscle may cause sarcopenia and thus be a clinical target in disease prevention.

AB - Purpose: Sarcopenia is a major problem of the elderly. Although little is known about the cause of sarcopenia, the intramuscular adipose tissue content (IMAC) is known to be a cause of sarcopenia. The aim of this study was to investigate the significance of IMAC as a cause of sarcopenia. Methods: We evaluated patients who underwent aneurysm repair and were monitored preoperatively and 3 years postoperatively by computed tomography (CT). The skeletal muscle area and IMAC were measured on preoperative L3 CT images. The clinical characteristics and risk factors for skeletal muscle wasting were assessed. Results: Among the 155 patients, 38 (24.5%) had > 10% skeletal muscle wasting 3 years after the operation. Patients with > 10% skeletal muscle wasting had higher IMACs of the iliopsoas (− 0.31 ± 0.01 vs. −0.45 ± 0.01, P < 0.001) muscles and higher rates of cerebrovascular infarctions (7.7 vs. 23.7%, P = 0.0068), lung cancer (0 vs. 10.5%, P < 0.001), and urgent operations (0.9 vs. 10.5%, P = 0.029) and a longer postoperative fasting period (1.3 ± 0.1 vs. 3.1 ± 0.9 days, P < 0.001) than those without > 10% skeletal muscle wasting. The IMAC of the iliopsoas muscle correlated strongly with skeletal muscle wasting (P < 0.05, r = 0.70). Conclusions: A high IMAC of the iliopsoas muscle may cause sarcopenia and thus be a clinical target in disease prevention.

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