High-resolution CT characteristics of poorly differentiated adenocarcinoma of the peripheral lung

Comparison with well differentiated adenocarcinoma

Hidetake Yabuuchi, Sadayuki Murayama, Junji Murakami, Norihisa Hashiguchi, Hiroyasu Soeda, Kenji Sugio, Kouji Masuda

Research output: Contribution to journalArticle

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Abstract

Objectives: The purpose of this study was to elucidate the characteristic high-resolution CT (HRCT) findings of poorly differentiated adenocarcinoma (PDA) in comparison with those of well differentiated adenocarcinoma (WDA). Materials and methods: We investigated the HRCT features of surgically resected PDAs (n=21) and WDAs (n=31). We analyzed the margin, CT attenuation, and internal architecture of the tumor and findings in the surrounding lung field, comparing them with the corresponding pathologic findings. Results: Smoothness of the greater part (full-1/2 round) of the tumor and solid appearance were more prevalent in PDAs than WDAs (81% vs. 32%, 100% vs. 35%) [p<0.01]. Air-bronchogram was prevalent in WDAs (58%), but was never seen in PDAs [p<0.01]. Ground-glass opacity in PDAs pathologically corresponded to inflammation and edema in the alveolar space. Conclusions: Smoothness of the tumor margin and solid appearance without air-bronchogram were more commonly found in PDA than in WDA. HRCT may predict the histological differentiation of adenocarcinoma in selected cases in which differentiation is inconclusive by sputum cytology and transbronchial or CT-guided biopsy.

Original languageEnglish
Pages (from-to)343-347
Number of pages5
JournalRadiation Medicine - Medical Imaging and Radiation Oncology
Volume18
Issue number6
Publication statusPublished - Dec 1 2000

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lungs
Adenocarcinoma
tumors
margins
high resolution
cytology
edema
air
opacity
Air
attenuation
Neoplasms
Sputum
glass
Glass
Cell Biology
Edema
Adenocarcinoma of lung
Inflammation
Biopsy

All Science Journal Classification (ASJC) codes

  • Radiation
  • Radiology Nuclear Medicine and imaging
  • Oncology

Cite this

High-resolution CT characteristics of poorly differentiated adenocarcinoma of the peripheral lung : Comparison with well differentiated adenocarcinoma. / Yabuuchi, Hidetake; Murayama, Sadayuki; Murakami, Junji; Hashiguchi, Norihisa; Soeda, Hiroyasu; Sugio, Kenji; Masuda, Kouji.

In: Radiation Medicine - Medical Imaging and Radiation Oncology, Vol. 18, No. 6, 01.12.2000, p. 343-347.

Research output: Contribution to journalArticle

Yabuuchi, Hidetake ; Murayama, Sadayuki ; Murakami, Junji ; Hashiguchi, Norihisa ; Soeda, Hiroyasu ; Sugio, Kenji ; Masuda, Kouji. / High-resolution CT characteristics of poorly differentiated adenocarcinoma of the peripheral lung : Comparison with well differentiated adenocarcinoma. In: Radiation Medicine - Medical Imaging and Radiation Oncology. 2000 ; Vol. 18, No. 6. pp. 343-347.
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