High-Resolution Imaging by Adaptive Optics Scanning Laser Ophthalmoscopy Reveals Two Morphologically Distinct Types of Retinal Hard Exudates

Muneo Yamaguchi, Shintaro Nakao, Yoshihiro Kaizu, Yoshiyuki Kobayashi, Takahito Nakama, Mitsuru Arima, Shigeo Yoshida, Yuji Oshima, Atsunobu Takeda, Yasuhiro Ikeda, Shizuo Mukai, Tatsuro Ishibashi, Koh Hei Sonoda

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Histological studies from autopsy specimens have characterized hard exudates as a composition of lipid-laden macrophages or noncellular materials including lipid and proteinaceous substances (hyaline substances). However, the characteristics of hard exudates in living patients have not been examined due to insufficient resolution of existing equipment. In this study, we used adaptive optics scanning laser ophthalmoscopy (AO-SLO) to examine the characteristics of hard exudates in patients with retinal vascular diseases. High resolution imaging using AO-SLO enables morphological classification of retinal hard exudates into two types, which could not be distinguished either on fundus examination or by spectral domain optical coherence tomography (SD-OCT). One, termed a round type, consisted of an accumulation of spherical particles (average diameter of particles: 26.9 ± 4.4 μm). The other, termed an irregular type, comprised an irregularly shaped hyper-reflective deposition. The retinal thickness in regions with round hard exudates was significantly greater than the thickness in regions with irregular hard exudates (P = 0.01 â †'0.02). This differentiation of retinal hard exudates in patients by AO-SLO may help in understanding the pathogenesis and clinical prognosis of retinal vascular diseases.

Original languageEnglish
Article number33574
JournalScientific reports
Volume6
DOIs
Publication statusPublished - Sep 19 2016

Fingerprint

Ophthalmoscopy
Exudates and Transudates
Lasers
Retinal Diseases
Retinal Vessels
Vascular Diseases
Lipids
Hyalin
Optical Coherence Tomography
Autopsy
Macrophages
Equipment and Supplies

All Science Journal Classification (ASJC) codes

  • General

Cite this

High-Resolution Imaging by Adaptive Optics Scanning Laser Ophthalmoscopy Reveals Two Morphologically Distinct Types of Retinal Hard Exudates. / Yamaguchi, Muneo; Nakao, Shintaro; Kaizu, Yoshihiro; Kobayashi, Yoshiyuki; Nakama, Takahito; Arima, Mitsuru; Yoshida, Shigeo; Oshima, Yuji; Takeda, Atsunobu; Ikeda, Yasuhiro; Mukai, Shizuo; Ishibashi, Tatsuro; Sonoda, Koh Hei.

In: Scientific reports, Vol. 6, 33574, 19.09.2016.

Research output: Contribution to journalArticle

Yamaguchi, Muneo ; Nakao, Shintaro ; Kaizu, Yoshihiro ; Kobayashi, Yoshiyuki ; Nakama, Takahito ; Arima, Mitsuru ; Yoshida, Shigeo ; Oshima, Yuji ; Takeda, Atsunobu ; Ikeda, Yasuhiro ; Mukai, Shizuo ; Ishibashi, Tatsuro ; Sonoda, Koh Hei. / High-Resolution Imaging by Adaptive Optics Scanning Laser Ophthalmoscopy Reveals Two Morphologically Distinct Types of Retinal Hard Exudates. In: Scientific reports. 2016 ; Vol. 6.
@article{e80db137442344c1a4df85f549386b0d,
title = "High-Resolution Imaging by Adaptive Optics Scanning Laser Ophthalmoscopy Reveals Two Morphologically Distinct Types of Retinal Hard Exudates",
abstract = "Histological studies from autopsy specimens have characterized hard exudates as a composition of lipid-laden macrophages or noncellular materials including lipid and proteinaceous substances (hyaline substances). However, the characteristics of hard exudates in living patients have not been examined due to insufficient resolution of existing equipment. In this study, we used adaptive optics scanning laser ophthalmoscopy (AO-SLO) to examine the characteristics of hard exudates in patients with retinal vascular diseases. High resolution imaging using AO-SLO enables morphological classification of retinal hard exudates into two types, which could not be distinguished either on fundus examination or by spectral domain optical coherence tomography (SD-OCT). One, termed a round type, consisted of an accumulation of spherical particles (average diameter of particles: 26.9 ± 4.4 μm). The other, termed an irregular type, comprised an irregularly shaped hyper-reflective deposition. The retinal thickness in regions with round hard exudates was significantly greater than the thickness in regions with irregular hard exudates (P = 0.01 {\^a} †'0.02). This differentiation of retinal hard exudates in patients by AO-SLO may help in understanding the pathogenesis and clinical prognosis of retinal vascular diseases.",
author = "Muneo Yamaguchi and Shintaro Nakao and Yoshihiro Kaizu and Yoshiyuki Kobayashi and Takahito Nakama and Mitsuru Arima and Shigeo Yoshida and Yuji Oshima and Atsunobu Takeda and Yasuhiro Ikeda and Shizuo Mukai and Tatsuro Ishibashi and Sonoda, {Koh Hei}",
year = "2016",
month = "9",
day = "19",
doi = "10.1038/srep33574",
language = "English",
volume = "6",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - High-Resolution Imaging by Adaptive Optics Scanning Laser Ophthalmoscopy Reveals Two Morphologically Distinct Types of Retinal Hard Exudates

AU - Yamaguchi, Muneo

AU - Nakao, Shintaro

AU - Kaizu, Yoshihiro

AU - Kobayashi, Yoshiyuki

AU - Nakama, Takahito

AU - Arima, Mitsuru

AU - Yoshida, Shigeo

AU - Oshima, Yuji

AU - Takeda, Atsunobu

AU - Ikeda, Yasuhiro

AU - Mukai, Shizuo

AU - Ishibashi, Tatsuro

AU - Sonoda, Koh Hei

PY - 2016/9/19

Y1 - 2016/9/19

N2 - Histological studies from autopsy specimens have characterized hard exudates as a composition of lipid-laden macrophages or noncellular materials including lipid and proteinaceous substances (hyaline substances). However, the characteristics of hard exudates in living patients have not been examined due to insufficient resolution of existing equipment. In this study, we used adaptive optics scanning laser ophthalmoscopy (AO-SLO) to examine the characteristics of hard exudates in patients with retinal vascular diseases. High resolution imaging using AO-SLO enables morphological classification of retinal hard exudates into two types, which could not be distinguished either on fundus examination or by spectral domain optical coherence tomography (SD-OCT). One, termed a round type, consisted of an accumulation of spherical particles (average diameter of particles: 26.9 ± 4.4 μm). The other, termed an irregular type, comprised an irregularly shaped hyper-reflective deposition. The retinal thickness in regions with round hard exudates was significantly greater than the thickness in regions with irregular hard exudates (P = 0.01 â †'0.02). This differentiation of retinal hard exudates in patients by AO-SLO may help in understanding the pathogenesis and clinical prognosis of retinal vascular diseases.

AB - Histological studies from autopsy specimens have characterized hard exudates as a composition of lipid-laden macrophages or noncellular materials including lipid and proteinaceous substances (hyaline substances). However, the characteristics of hard exudates in living patients have not been examined due to insufficient resolution of existing equipment. In this study, we used adaptive optics scanning laser ophthalmoscopy (AO-SLO) to examine the characteristics of hard exudates in patients with retinal vascular diseases. High resolution imaging using AO-SLO enables morphological classification of retinal hard exudates into two types, which could not be distinguished either on fundus examination or by spectral domain optical coherence tomography (SD-OCT). One, termed a round type, consisted of an accumulation of spherical particles (average diameter of particles: 26.9 ± 4.4 μm). The other, termed an irregular type, comprised an irregularly shaped hyper-reflective deposition. The retinal thickness in regions with round hard exudates was significantly greater than the thickness in regions with irregular hard exudates (P = 0.01 â †'0.02). This differentiation of retinal hard exudates in patients by AO-SLO may help in understanding the pathogenesis and clinical prognosis of retinal vascular diseases.

UR - http://www.scopus.com/inward/record.url?scp=84988409770&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84988409770&partnerID=8YFLogxK

U2 - 10.1038/srep33574

DO - 10.1038/srep33574

M3 - Article

AN - SCOPUS:84988409770

VL - 6

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 33574

ER -