High-resolution visualization of tumours in rabbit lung using refraction contrast X-ray imaging

Toshihiro Sera, K. Uesugi, N. Yagi, K. Umetani, M. Kobatake, S. Imai

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Contrast enhancement by refraction was used to visualize tumours in the rabbit lung. VX2 tumour cells were intravenously injected into a rabbit. After 14 days the rabbit was euthanized and the lungs were imaged. Refraction-enhanced X-ray images were obtained with a sample-to-detector distance of 2.65-6 m. The beamline BL20B2 at the SPring-8 synchrotron radiation facility was used for the experiment, with a monochromatic X-ray beam with an energy of 33.2 keV. In the case of projection images, it was found that refraction did not help visualization of small tumours: the nodules did not show up with sharply defined edges. In tomography, tumours with a size of 1-10 mm were clearly visualized, together with blood vessels with a diameter down to 0.4 mm. These results show that refraction-enhanced imaging may be useful in human lung tomography to find small tumours.

Original languageEnglish
Pages (from-to)S54-S57
JournalEuropean Journal of Radiology
Volume68
Issue number3 SUPPL.
DOIs
Publication statusPublished - Jan 1 2008
Externally publishedYes

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X-Rays
Rabbits
Lung
Neoplasms
Tomography
Synchrotrons
Blood Vessels
Radiation

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

High-resolution visualization of tumours in rabbit lung using refraction contrast X-ray imaging. / Sera, Toshihiro; Uesugi, K.; Yagi, N.; Umetani, K.; Kobatake, M.; Imai, S.

In: European Journal of Radiology, Vol. 68, No. 3 SUPPL., 01.01.2008, p. S54-S57.

Research output: Contribution to journalArticle

Sera, Toshihiro ; Uesugi, K. ; Yagi, N. ; Umetani, K. ; Kobatake, M. ; Imai, S. / High-resolution visualization of tumours in rabbit lung using refraction contrast X-ray imaging. In: European Journal of Radiology. 2008 ; Vol. 68, No. 3 SUPPL. pp. S54-S57.
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