Abstract
Contrast enhancement by refraction was used to visualize tumours in the rabbit lung. VX2 tumour cells were intravenously injected into a rabbit. After 14 days the rabbit was euthanized and the lungs were imaged. Refraction-enhanced X-ray images were obtained with a sample-to-detector distance of 2.65-6 m. The beamline BL20B2 at the SPring-8 synchrotron radiation facility was used for the experiment, with a monochromatic X-ray beam with an energy of 33.2 keV. In the case of projection images, it was found that refraction did not help visualization of small tumours: the nodules did not show up with sharply defined edges. In tomography, tumours with a size of 1-10 mm were clearly visualized, together with blood vessels with a diameter down to 0.4 mm. These results show that refraction-enhanced imaging may be useful in human lung tomography to find small tumours.
| Original language | English |
|---|---|
| Pages (from-to) | S54-S57 |
| Journal | European Journal of Radiology |
| Volume | 68 |
| Issue number | 3 SUPPL. |
| DOIs | |
| Publication status | Published - Jan 1 2008 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Radiology Nuclear Medicine and imaging
Cite this
High-resolution visualization of tumours in rabbit lung using refraction contrast X-ray imaging. / Sera, Toshihiro; Uesugi, K.; Yagi, N.; Umetani, K.; Kobatake, M.; Imai, S.
In: European Journal of Radiology, Vol. 68, No. 3 SUPPL., 01.01.2008, p. S54-S57.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - High-resolution visualization of tumours in rabbit lung using refraction contrast X-ray imaging
AU - Sera, Toshihiro
AU - Uesugi, K.
AU - Yagi, N.
AU - Umetani, K.
AU - Kobatake, M.
AU - Imai, S.
PY - 2008/1/1
Y1 - 2008/1/1
N2 - Contrast enhancement by refraction was used to visualize tumours in the rabbit lung. VX2 tumour cells were intravenously injected into a rabbit. After 14 days the rabbit was euthanized and the lungs were imaged. Refraction-enhanced X-ray images were obtained with a sample-to-detector distance of 2.65-6 m. The beamline BL20B2 at the SPring-8 synchrotron radiation facility was used for the experiment, with a monochromatic X-ray beam with an energy of 33.2 keV. In the case of projection images, it was found that refraction did not help visualization of small tumours: the nodules did not show up with sharply defined edges. In tomography, tumours with a size of 1-10 mm were clearly visualized, together with blood vessels with a diameter down to 0.4 mm. These results show that refraction-enhanced imaging may be useful in human lung tomography to find small tumours.
AB - Contrast enhancement by refraction was used to visualize tumours in the rabbit lung. VX2 tumour cells were intravenously injected into a rabbit. After 14 days the rabbit was euthanized and the lungs were imaged. Refraction-enhanced X-ray images were obtained with a sample-to-detector distance of 2.65-6 m. The beamline BL20B2 at the SPring-8 synchrotron radiation facility was used for the experiment, with a monochromatic X-ray beam with an energy of 33.2 keV. In the case of projection images, it was found that refraction did not help visualization of small tumours: the nodules did not show up with sharply defined edges. In tomography, tumours with a size of 1-10 mm were clearly visualized, together with blood vessels with a diameter down to 0.4 mm. These results show that refraction-enhanced imaging may be useful in human lung tomography to find small tumours.
UR - http://www.scopus.com/inward/record.url?scp=56549095506&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=56549095506&partnerID=8YFLogxK
U2 - 10.1016/j.ejrad.2008.04.030
DO - 10.1016/j.ejrad.2008.04.030
M3 - Article
C2 - 18586428
AN - SCOPUS:56549095506
VL - 68
SP - S54-S57
JO - European Journal of Radiology
JF - European Journal of Radiology
SN - 0720-048X
IS - 3 SUPPL.
ER -