"High-risk stigmata" of the 2012 international consensus guidelines correlate with the malignant grade of branch duct intraductal papillary mucinous neoplasms of the pancreas

Teppei Aso, Takao Ohtsuka, Taketo Matsunaga, Hideyo Kimura, Yusuke Watanabe, Koji Tamura, Noboru Ideno, Takashi Osoegawa, Shunnichi Takahata, Koji Shindo, Yasuhiro Ushijima, Shinichi Aishima, Yoshinao Oda, Tetsuhide Ito, Kazuhiro Mizumoto, Masao Tanaka

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Methods: The medical records of 100 consecutive patients who underwent pancreatectomy for IPMNs were retrospectively reviewed. Seventy patients with branch duct IPMNs (BD-IPMNs) were stratified into 3 groups. The relationships between the number of predictive factors and his-topathologic grade were investigated.

Objectives: The 2012 international consensus guidelines for the management of intraductal papillary mucinous neoplasm (IPMN) of the pancreas stratified patients into 2 clinical categories, "high-risk stigmata" and "worrisome features," and recommended different therapeutic strategies for these groups. The aim of this study was to elucidate the significance of these categories in terms of predicting malignant IPMNs.

Results: The prevalence rates of malignant IPMN, invasive carcinoma, and lymph node metastasis in the high-risk group were 80%, 55%, and 20%, respectively, with these percentages significantly increasing in a step-wise manner according to the number of predictive factors. In contrast, there was no significant correlation between the number of worrisome features and grade of malignancy in patients stratified as having worrisome BD-IPMNs.

Conclusions: The number of high-risk stigmata correlated significantly with the grade of malignancy of BD-IPMNs. The presence of at least 1 high-risk stigma in patients with BD-IPMNs indicates a need for pancrea-tectomy with lymphadenectomy.

Original languageEnglish
Pages (from-to)1239-1243
Number of pages5
JournalPancreas
Volume43
Issue number8
DOIs
Publication statusPublished - Nov 10 2014

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Christianity
Pancreatic Neoplasms
Guidelines
Neoplasms
Pancreatectomy
Lymph Node Excision
Medical Records
Lymph Nodes
Neoplasm Metastasis
Carcinoma

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

Cite this

"High-risk stigmata" of the 2012 international consensus guidelines correlate with the malignant grade of branch duct intraductal papillary mucinous neoplasms of the pancreas. / Aso, Teppei; Ohtsuka, Takao; Matsunaga, Taketo; Kimura, Hideyo; Watanabe, Yusuke; Tamura, Koji; Ideno, Noboru; Osoegawa, Takashi; Takahata, Shunnichi; Shindo, Koji; Ushijima, Yasuhiro; Aishima, Shinichi; Oda, Yoshinao; Ito, Tetsuhide; Mizumoto, Kazuhiro; Tanaka, Masao.

In: Pancreas, Vol. 43, No. 8, 10.11.2014, p. 1239-1243.

Research output: Contribution to journalArticle

Aso, Teppei ; Ohtsuka, Takao ; Matsunaga, Taketo ; Kimura, Hideyo ; Watanabe, Yusuke ; Tamura, Koji ; Ideno, Noboru ; Osoegawa, Takashi ; Takahata, Shunnichi ; Shindo, Koji ; Ushijima, Yasuhiro ; Aishima, Shinichi ; Oda, Yoshinao ; Ito, Tetsuhide ; Mizumoto, Kazuhiro ; Tanaka, Masao. / "High-risk stigmata" of the 2012 international consensus guidelines correlate with the malignant grade of branch duct intraductal papillary mucinous neoplasms of the pancreas. In: Pancreas. 2014 ; Vol. 43, No. 8. pp. 1239-1243.
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abstract = "Methods: The medical records of 100 consecutive patients who underwent pancreatectomy for IPMNs were retrospectively reviewed. Seventy patients with branch duct IPMNs (BD-IPMNs) were stratified into 3 groups. The relationships between the number of predictive factors and his-topathologic grade were investigated.Objectives: The 2012 international consensus guidelines for the management of intraductal papillary mucinous neoplasm (IPMN) of the pancreas stratified patients into 2 clinical categories, {"}high-risk stigmata{"} and {"}worrisome features,{"} and recommended different therapeutic strategies for these groups. The aim of this study was to elucidate the significance of these categories in terms of predicting malignant IPMNs.Results: The prevalence rates of malignant IPMN, invasive carcinoma, and lymph node metastasis in the high-risk group were 80{\%}, 55{\%}, and 20{\%}, respectively, with these percentages significantly increasing in a step-wise manner according to the number of predictive factors. In contrast, there was no significant correlation between the number of worrisome features and grade of malignancy in patients stratified as having worrisome BD-IPMNs.Conclusions: The number of high-risk stigmata correlated significantly with the grade of malignancy of BD-IPMNs. The presence of at least 1 high-risk stigma in patients with BD-IPMNs indicates a need for pancrea-tectomy with lymphadenectomy.",
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T1 - "High-risk stigmata" of the 2012 international consensus guidelines correlate with the malignant grade of branch duct intraductal papillary mucinous neoplasms of the pancreas

AU - Aso, Teppei

AU - Ohtsuka, Takao

AU - Matsunaga, Taketo

AU - Kimura, Hideyo

AU - Watanabe, Yusuke

AU - Tamura, Koji

AU - Ideno, Noboru

AU - Osoegawa, Takashi

AU - Takahata, Shunnichi

AU - Shindo, Koji

AU - Ushijima, Yasuhiro

AU - Aishima, Shinichi

AU - Oda, Yoshinao

AU - Ito, Tetsuhide

AU - Mizumoto, Kazuhiro

AU - Tanaka, Masao

PY - 2014/11/10

Y1 - 2014/11/10

N2 - Methods: The medical records of 100 consecutive patients who underwent pancreatectomy for IPMNs were retrospectively reviewed. Seventy patients with branch duct IPMNs (BD-IPMNs) were stratified into 3 groups. The relationships between the number of predictive factors and his-topathologic grade were investigated.Objectives: The 2012 international consensus guidelines for the management of intraductal papillary mucinous neoplasm (IPMN) of the pancreas stratified patients into 2 clinical categories, "high-risk stigmata" and "worrisome features," and recommended different therapeutic strategies for these groups. The aim of this study was to elucidate the significance of these categories in terms of predicting malignant IPMNs.Results: The prevalence rates of malignant IPMN, invasive carcinoma, and lymph node metastasis in the high-risk group were 80%, 55%, and 20%, respectively, with these percentages significantly increasing in a step-wise manner according to the number of predictive factors. In contrast, there was no significant correlation between the number of worrisome features and grade of malignancy in patients stratified as having worrisome BD-IPMNs.Conclusions: The number of high-risk stigmata correlated significantly with the grade of malignancy of BD-IPMNs. The presence of at least 1 high-risk stigma in patients with BD-IPMNs indicates a need for pancrea-tectomy with lymphadenectomy.

AB - Methods: The medical records of 100 consecutive patients who underwent pancreatectomy for IPMNs were retrospectively reviewed. Seventy patients with branch duct IPMNs (BD-IPMNs) were stratified into 3 groups. The relationships between the number of predictive factors and his-topathologic grade were investigated.Objectives: The 2012 international consensus guidelines for the management of intraductal papillary mucinous neoplasm (IPMN) of the pancreas stratified patients into 2 clinical categories, "high-risk stigmata" and "worrisome features," and recommended different therapeutic strategies for these groups. The aim of this study was to elucidate the significance of these categories in terms of predicting malignant IPMNs.Results: The prevalence rates of malignant IPMN, invasive carcinoma, and lymph node metastasis in the high-risk group were 80%, 55%, and 20%, respectively, with these percentages significantly increasing in a step-wise manner according to the number of predictive factors. In contrast, there was no significant correlation between the number of worrisome features and grade of malignancy in patients stratified as having worrisome BD-IPMNs.Conclusions: The number of high-risk stigmata correlated significantly with the grade of malignancy of BD-IPMNs. The presence of at least 1 high-risk stigma in patients with BD-IPMNs indicates a need for pancrea-tectomy with lymphadenectomy.

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