Abstract
Methods: The medical records of 100 consecutive patients who underwent pancreatectomy for IPMNs were retrospectively reviewed. Seventy patients with branch duct IPMNs (BD-IPMNs) were stratified into 3 groups. The relationships between the number of predictive factors and his-topathologic grade were investigated.
Objectives: The 2012 international consensus guidelines for the management of intraductal papillary mucinous neoplasm (IPMN) of the pancreas stratified patients into 2 clinical categories, "high-risk stigmata" and "worrisome features," and recommended different therapeutic strategies for these groups. The aim of this study was to elucidate the significance of these categories in terms of predicting malignant IPMNs.
Results: The prevalence rates of malignant IPMN, invasive carcinoma, and lymph node metastasis in the high-risk group were 80%, 55%, and 20%, respectively, with these percentages significantly increasing in a step-wise manner according to the number of predictive factors. In contrast, there was no significant correlation between the number of worrisome features and grade of malignancy in patients stratified as having worrisome BD-IPMNs.
Conclusions: The number of high-risk stigmata correlated significantly with the grade of malignancy of BD-IPMNs. The presence of at least 1 high-risk stigma in patients with BD-IPMNs indicates a need for pancrea-tectomy with lymphadenectomy.
| Original language | English |
|---|---|
| Pages (from-to) | 1239-1243 |
| Number of pages | 5 |
| Journal | Pancreas |
| Volume | 43 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Nov 10 2014 |
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All Science Journal Classification (ASJC) codes
- Internal Medicine
- Endocrinology, Diabetes and Metabolism
- Hepatology
- Endocrinology
Cite this
"High-risk stigmata" of the 2012 international consensus guidelines correlate with the malignant grade of branch duct intraductal papillary mucinous neoplasms of the pancreas. / Aso, Teppei; Ohtsuka, Takao; Matsunaga, Taketo; Kimura, Hideyo; Watanabe, Yusuke; Tamura, Koji; Ideno, Noboru; Osoegawa, Takashi; Takahata, Shunnichi; Shindo, Koji; Ushijima, Yasuhiro; Aishima, Shinichi; Oda, Yoshinao; Ito, Tetsuhide; Mizumoto, Kazuhiro; Tanaka, Masao.
In: Pancreas, Vol. 43, No. 8, 10.11.2014, p. 1239-1243.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - "High-risk stigmata" of the 2012 international consensus guidelines correlate with the malignant grade of branch duct intraductal papillary mucinous neoplasms of the pancreas
AU - Aso, Teppei
AU - Ohtsuka, Takao
AU - Matsunaga, Taketo
AU - Kimura, Hideyo
AU - Watanabe, Yusuke
AU - Tamura, Koji
AU - Ideno, Noboru
AU - Osoegawa, Takashi
AU - Takahata, Shunnichi
AU - Shindo, Koji
AU - Ushijima, Yasuhiro
AU - Aishima, Shinichi
AU - Oda, Yoshinao
AU - Ito, Tetsuhide
AU - Mizumoto, Kazuhiro
AU - Tanaka, Masao
PY - 2014/11/10
Y1 - 2014/11/10
N2 - Methods: The medical records of 100 consecutive patients who underwent pancreatectomy for IPMNs were retrospectively reviewed. Seventy patients with branch duct IPMNs (BD-IPMNs) were stratified into 3 groups. The relationships between the number of predictive factors and his-topathologic grade were investigated.Objectives: The 2012 international consensus guidelines for the management of intraductal papillary mucinous neoplasm (IPMN) of the pancreas stratified patients into 2 clinical categories, "high-risk stigmata" and "worrisome features," and recommended different therapeutic strategies for these groups. The aim of this study was to elucidate the significance of these categories in terms of predicting malignant IPMNs.Results: The prevalence rates of malignant IPMN, invasive carcinoma, and lymph node metastasis in the high-risk group were 80%, 55%, and 20%, respectively, with these percentages significantly increasing in a step-wise manner according to the number of predictive factors. In contrast, there was no significant correlation between the number of worrisome features and grade of malignancy in patients stratified as having worrisome BD-IPMNs.Conclusions: The number of high-risk stigmata correlated significantly with the grade of malignancy of BD-IPMNs. The presence of at least 1 high-risk stigma in patients with BD-IPMNs indicates a need for pancrea-tectomy with lymphadenectomy.
AB - Methods: The medical records of 100 consecutive patients who underwent pancreatectomy for IPMNs were retrospectively reviewed. Seventy patients with branch duct IPMNs (BD-IPMNs) were stratified into 3 groups. The relationships between the number of predictive factors and his-topathologic grade were investigated.Objectives: The 2012 international consensus guidelines for the management of intraductal papillary mucinous neoplasm (IPMN) of the pancreas stratified patients into 2 clinical categories, "high-risk stigmata" and "worrisome features," and recommended different therapeutic strategies for these groups. The aim of this study was to elucidate the significance of these categories in terms of predicting malignant IPMNs.Results: The prevalence rates of malignant IPMN, invasive carcinoma, and lymph node metastasis in the high-risk group were 80%, 55%, and 20%, respectively, with these percentages significantly increasing in a step-wise manner according to the number of predictive factors. In contrast, there was no significant correlation between the number of worrisome features and grade of malignancy in patients stratified as having worrisome BD-IPMNs.Conclusions: The number of high-risk stigmata correlated significantly with the grade of malignancy of BD-IPMNs. The presence of at least 1 high-risk stigma in patients with BD-IPMNs indicates a need for pancrea-tectomy with lymphadenectomy.
UR - http://www.scopus.com/inward/record.url?scp=84916594956&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84916594956&partnerID=8YFLogxK
U2 - 10.1097/MPA.0000000000000199
DO - 10.1097/MPA.0000000000000199
M3 - Article
C2 - 25036910
AN - SCOPUS:84916594956
VL - 43
SP - 1239
EP - 1243
JO - Pancreas
JF - Pancreas
SN - 0885-3177
IS - 8
ER -