High-Tc SQUID system for biological immunoassays

Keiji Enpuku, M. Hotta, A. Nakahodo

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

A high-Tc SQUID system is developed for the application to biological immunoassay, i.e., for the detection of an antigen with a magnetically labeled antibody. In order to improve the system performance, two issues are studied. One is the use of a gradiometer to suppress the system noise due to residual environmental noise. It is shown that the noise of the gradiometer system is five times smaller than that of the magnetometer system. The other is to increase the signal field from the magnetic marker. The signal can be increased by increasing an applied field Bex or by using remanence of the marker. If these improvements were fully developed, it will be possible to develop the system that is 100 times more sensitive than the conventional optical method.

Original languageEnglish
Pages (from-to)1462-1465
Number of pages4
JournalPhysica C: Superconductivity and its applications
Volume357-360
Issue numberSUPPL. 1
DOIs
Publication statusPublished - Sep 1 2001

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immunoassay
Remanence
SQUIDs
Magnetometers
Antigens
Antibodies
gradiometers
markers
antigens
remanence
antibodies
magnetometers
optics

All Science Journal Classification (ASJC) codes

  • Condensed Matter Physics

Cite this

High-Tc SQUID system for biological immunoassays. / Enpuku, Keiji; Hotta, M.; Nakahodo, A.

In: Physica C: Superconductivity and its applications, Vol. 357-360, No. SUPPL. 1, 01.09.2001, p. 1462-1465.

Research output: Contribution to journalArticle

Enpuku, Keiji ; Hotta, M. ; Nakahodo, A. / High-Tc SQUID system for biological immunoassays. In: Physica C: Superconductivity and its applications. 2001 ; Vol. 357-360, No. SUPPL. 1. pp. 1462-1465.
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