High Tc SQUID system and magnetic marker for biological immunoassays

K. Enpuku; D. Kuroda; T. Q. Yang; K. Yoshinaga

doi:10.1109/TASC.2003.813856

High T_c SQUID system and magnetic marker for biological immunoassays

K. Enpuku, D. Kuroda, T. Q. Yang, K. Yoshinaga

Superconductive Systems Engineering Laboratory

Research output: Contribution to journal › Conference article › peer-review

9 Citations (Scopus)

Abstract

High T_c SQUID system is developed for the detection of the biological binding-reaction between antigen and its antibody. In this measurement, the antibody is labeled with magnetic nanoparticles, and the magnetic signal from the nanoparticles is measured. The excitation field of a few mT is applied in parallel to the SQUID in order to magnetize the nanoparticles. Due to mechanical misalignment, however, the vertical component of the excitation field couples to the SQUID, and degrades the system performance. In order to solve this problem, we develop two methods. One is the use of a compensation field in the case of the flux dam, and the other is the use of a switch instead of the flux dam. We also develop a magnetic marker utilizing Fe₃O₄ nanoparticle with diameter of d = 25 nm. The nanoparticle is embedded in the polymer with typical diameter of 80 nm, and COOH is attached around the surface of the polymer. The properties of the marker are discussed.

Original language	English
Pages (from-to)	371-376
Number of pages	6
Journal	IEEE Transactions on Applied Superconductivity
Volume	13
Issue number	2 I
DOIs	https://doi.org/10.1109/TASC.2003.813856
Publication status	Published - Jun 2003
Event	2002 Applied Superconductivity Conference - Houston, TX, United States Duration: Aug 4 2002 → Aug 9 2002

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Electrical and Electronic Engineering

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10.1109/TASC.2003.813856

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title = "High Tc SQUID system and magnetic marker for biological immunoassays",

abstract = "High Tc SQUID system is developed for the detection of the biological binding-reaction between antigen and its antibody. In this measurement, the antibody is labeled with magnetic nanoparticles, and the magnetic signal from the nanoparticles is measured. The excitation field of a few mT is applied in parallel to the SQUID in order to magnetize the nanoparticles. Due to mechanical misalignment, however, the vertical component of the excitation field couples to the SQUID, and degrades the system performance. In order to solve this problem, we develop two methods. One is the use of a compensation field in the case of the flux dam, and the other is the use of a switch instead of the flux dam. We also develop a magnetic marker utilizing Fe3O4 nanoparticle with diameter of d = 25 nm. The nanoparticle is embedded in the polymer with typical diameter of 80 nm, and COOH is attached around the surface of the polymer. The properties of the marker are discussed.",

author = "K. Enpuku and D. Kuroda and Yang, {T. Q.} and K. Yoshinaga",

note = "Funding Information: Manuscript received August 5, 2002. This work is supported in part by the Tateisi Science and Technology Foundation, and Fukuoka Industry, Science and Technology Foundation.; 2002 Applied Superconductivity Conference ; Conference date: 04-08-2002 Through 09-08-2002",

year = "2003",

month = jun,

doi = "10.1109/TASC.2003.813856",

language = "English",

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pages = "371--376",

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TY - JOUR

T1 - High Tc SQUID system and magnetic marker for biological immunoassays

AU - Enpuku, K.

AU - Kuroda, D.

AU - Yang, T. Q.

AU - Yoshinaga, K.

N1 - Funding Information: Manuscript received August 5, 2002. This work is supported in part by the Tateisi Science and Technology Foundation, and Fukuoka Industry, Science and Technology Foundation.

PY - 2003/6

Y1 - 2003/6

N2 - High Tc SQUID system is developed for the detection of the biological binding-reaction between antigen and its antibody. In this measurement, the antibody is labeled with magnetic nanoparticles, and the magnetic signal from the nanoparticles is measured. The excitation field of a few mT is applied in parallel to the SQUID in order to magnetize the nanoparticles. Due to mechanical misalignment, however, the vertical component of the excitation field couples to the SQUID, and degrades the system performance. In order to solve this problem, we develop two methods. One is the use of a compensation field in the case of the flux dam, and the other is the use of a switch instead of the flux dam. We also develop a magnetic marker utilizing Fe3O4 nanoparticle with diameter of d = 25 nm. The nanoparticle is embedded in the polymer with typical diameter of 80 nm, and COOH is attached around the surface of the polymer. The properties of the marker are discussed.

AB - High Tc SQUID system is developed for the detection of the biological binding-reaction between antigen and its antibody. In this measurement, the antibody is labeled with magnetic nanoparticles, and the magnetic signal from the nanoparticles is measured. The excitation field of a few mT is applied in parallel to the SQUID in order to magnetize the nanoparticles. Due to mechanical misalignment, however, the vertical component of the excitation field couples to the SQUID, and degrades the system performance. In order to solve this problem, we develop two methods. One is the use of a compensation field in the case of the flux dam, and the other is the use of a switch instead of the flux dam. We also develop a magnetic marker utilizing Fe3O4 nanoparticle with diameter of d = 25 nm. The nanoparticle is embedded in the polymer with typical diameter of 80 nm, and COOH is attached around the surface of the polymer. The properties of the marker are discussed.

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SN - 1051-8223

VL - 13

SP - 371

EP - 376

JO - IEEE Transactions on Applied Superconductivity

JF - IEEE Transactions on Applied Superconductivity

IS - 2 I

T2 - 2002 Applied Superconductivity Conference

Y2 - 4 August 2002 through 9 August 2002

ER -

High T_c SQUID system and magnetic marker for biological immunoassays

Abstract

All Science Journal Classification (ASJC) codes

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