High-Tc SQUID system for biological immunoassays

K. Enpuku; M. Hotta; A. Nakahodo

doi:10.1016/S0921-4534(01)00586-X

High-T_c SQUID system for biological immunoassays

K. Enpuku, M. Hotta, A. Nakahodo

Superconductive Systems Engineering Laboratory

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

A high-T_c SQUID system is developed for the application to biological immunoassay, i.e., for the detection of an antigen with a magnetically labeled antibody. In order to improve the system performance, two issues are studied. One is the use of a gradiometer to suppress the system noise due to residual environmental noise. It is shown that the noise of the gradiometer system is five times smaller than that of the magnetometer system. The other is to increase the signal field from the magnetic marker. The signal can be increased by increasing an applied field B_ex or by using remanence of the marker. If these improvements were fully developed, it will be possible to develop the system that is 100 times more sensitive than the conventional optical method.

Original language	English
Pages (from-to)	1462-1465
Number of pages	4
Journal	Physica C: Superconductivity and its applications
Volume	357-360
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1016/S0921-4534(01)00586-X
Publication status	Published - Sept 2001

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Energy Engineering and Power Technology
Electrical and Electronic Engineering

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10.1016/S0921-4534(01)00586-X

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abstract = "A high-Tc SQUID system is developed for the application to biological immunoassay, i.e., for the detection of an antigen with a magnetically labeled antibody. In order to improve the system performance, two issues are studied. One is the use of a gradiometer to suppress the system noise due to residual environmental noise. It is shown that the noise of the gradiometer system is five times smaller than that of the magnetometer system. The other is to increase the signal field from the magnetic marker. The signal can be increased by increasing an applied field Bex or by using remanence of the marker. If these improvements were fully developed, it will be possible to develop the system that is 100 times more sensitive than the conventional optical method.",

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High-T_c SQUID system for biological immunoassays

Abstract

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