Highly anti-diastereoselective reduction of 2-alkyl-3-oxo amides by potassium triethylborohydride

Yoshio Ito, Tsutomu Katsuki, Masaru Yamaguchi

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Potassium triethylborohydride was found to reduce 2-alkyl-3-oxo amides to the corresponding 3-hydroxy amides with excellent anti-diastereoselectivity (>99:1), and in combination with asymmetric acylation, a useful route to optically active anti-2-alkyl-3-hydroxy acids was developed.

Original languageEnglish
Pages (from-to)4643-4646
Number of pages4
JournalTetrahedron Letters
Volume26
Issue number38
DOIs
Publication statusPublished - 1985

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Amides
Potassium
Acylation
Hydroxy Acids

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Highly anti-diastereoselective reduction of 2-alkyl-3-oxo amides by potassium triethylborohydride. / Ito, Yoshio; Katsuki, Tsutomu; Yamaguchi, Masaru.

In: Tetrahedron Letters, Vol. 26, No. 38, 1985, p. 4643-4646.

Research output: Contribution to journalArticle

Ito, Yoshio ; Katsuki, Tsutomu ; Yamaguchi, Masaru. / Highly anti-diastereoselective reduction of 2-alkyl-3-oxo amides by potassium triethylborohydride. In: Tetrahedron Letters. 1985 ; Vol. 26, No. 38. pp. 4643-4646.
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