Abstract
Potassium triethylborohydride was found to reduce 2-alkyl-3-oxo amides to the corresponding 3-hydroxy amides with excellent anti-diastereoselectivity (>99:1), and in combination with asymmetric acylation, a useful route to optically active anti-2-alkyl-3-hydroxy acids was developed.
| Original language | English |
|---|---|
| Pages (from-to) | 4643-4646 |
| Number of pages | 4 |
| Journal | Tetrahedron Letters |
| Volume | 26 |
| Issue number | 38 |
| DOIs | |
| Publication status | Published - 1985 |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Drug Discovery
- Organic Chemistry
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Cite this
Ito, Y., Katsuki, T., & Yamaguchi, M. (1985). Highly anti-diastereoselective reduction of 2-alkyl-3-oxo amides by potassium triethylborohydride. Tetrahedron Letters, 26(38), 4643-4646. https://doi.org/10.1016/S0040-4039(00)98774-4