Abstract
Potassium triethylborohydride was found to reduce 2-alkyl-3-oxo amides to the corresponding 3-hydroxy amides with excellent anti-diastereoselectivity (>99:1), and in combination with asymmetric acylation, a useful route to optically active anti-2-alkyl-3-hydroxy acids was developed.
| Original language | English |
|---|---|
| Pages (from-to) | 4643-4646 |
| Number of pages | 4 |
| Journal | Tetrahedron Letters |
| Volume | 26 |
| Issue number | 38 |
| DOIs | |
| Publication status | Published - 1985 |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Drug Discovery
- Organic Chemistry
Cite this
Highly anti-diastereoselective reduction of 2-alkyl-3-oxo amides by potassium triethylborohydride. / Ito, Yoshio; Katsuki, Tsutomu; Yamaguchi, Masaru.
In: Tetrahedron Letters, Vol. 26, No. 38, 1985, p. 4643-4646.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Highly anti-diastereoselective reduction of 2-alkyl-3-oxo amides by potassium triethylborohydride
AU - Ito, Yoshio
AU - Katsuki, Tsutomu
AU - Yamaguchi, Masaru
PY - 1985
Y1 - 1985
N2 - Potassium triethylborohydride was found to reduce 2-alkyl-3-oxo amides to the corresponding 3-hydroxy amides with excellent anti-diastereoselectivity (>99:1), and in combination with asymmetric acylation, a useful route to optically active anti-2-alkyl-3-hydroxy acids was developed.
AB - Potassium triethylborohydride was found to reduce 2-alkyl-3-oxo amides to the corresponding 3-hydroxy amides with excellent anti-diastereoselectivity (>99:1), and in combination with asymmetric acylation, a useful route to optically active anti-2-alkyl-3-hydroxy acids was developed.
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UR - http://www.scopus.com/inward/citedby.url?scp=0000803728&partnerID=8YFLogxK
U2 - 10.1016/S0040-4039(00)98774-4
DO - 10.1016/S0040-4039(00)98774-4
M3 - Article
AN - SCOPUS:0000803728
VL - 26
SP - 4643
EP - 4646
JO - Tetrahedron Letters
JF - Tetrahedron Letters
SN - 0040-4039
IS - 38
ER -