Highly efficient and low toxic skin penetrants composed of amino acid ionic liquids

Shin Ya Furukawa, Gaku Hattori, Shinji Sakai, Noriho Kamiya

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Herein, we introduce an amino acid ester (AAE) as a potent biocompatible counter ion to formulate ionic liquefied active pharmaceutical ingredients. By equimolar pairing of a non-steroidal anti-inflammatory drug (NSAID) as the anion and the AAE as the cation, the liquid formulation was feasibly obtained. In vitro drug permeation results using pig skin revealed a significant enhancement of the transdermal delivery of the ionic liquefied NSAIDs. The AAE showed much lower cytotoxicity to mouse fibroblast L929 cells when compared with that of conventional counter cations, indicating the significant potential of the AAE in the development of new ionic liquid drug formulations.

Original languageEnglish
Pages (from-to)87753-87755
Number of pages3
JournalRSC Advances
Volume6
Issue number90
DOIs
Publication statusPublished - Jan 1 2016

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Ionic Liquids
Poisons
Ionic liquids
Amino acids
Skin
Esters
Amino Acids
Cations
Positive ions
Pharmaceutical Preparations
Radiation counters
Non-Steroidal Anti-Inflammatory Agents
Fibroblasts
Cytotoxicity
Permeation
Drug products
Anions
Anti-Inflammatory Agents
Negative ions
Liquids

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

Highly efficient and low toxic skin penetrants composed of amino acid ionic liquids. / Furukawa, Shin Ya; Hattori, Gaku; Sakai, Shinji; Kamiya, Noriho.

In: RSC Advances, Vol. 6, No. 90, 01.01.2016, p. 87753-87755.

Research output: Contribution to journalArticle

Furukawa, Shin Ya ; Hattori, Gaku ; Sakai, Shinji ; Kamiya, Noriho. / Highly efficient and low toxic skin penetrants composed of amino acid ionic liquids. In: RSC Advances. 2016 ; Vol. 6, No. 90. pp. 87753-87755.
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