Highly enantioselective Baeyer-Villiger oxidation using Zr(salen) complex as catalyst

Akira Watanabe, Tatsuya Uchida, Katsuji Ito, Tsutomu Katsuki

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Abstract

(R, R)-Zr(salen) complex was found to serve as an efficient catalyst for asymmetric Baeyer-Villiger oxidation of pro-chiral and racemic ketones using urea·hydrogen peroxide as the terminal oxidant: for example, high enantioselectivity of 87% ee was achieved in the Baeyer-Villiger reaction of 3-phenylcyclobutanone.

Original languageEnglish
Pages (from-to)4481-4485
Number of pages5
JournalTetrahedron Letters
Volume43
Issue number25
DOIs
Publication statusPublished - Jan 1 2002

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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