Highly enantioselective (OC)Ru(salen)-catalyzed sulfimidation using N-alkoxycarbonyl azide as nitrene precursor

Yuusuke Tamura, Tatsuya Uchida, Tsutomu Katsuki

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Enantioselective imidation of alkyl aryl sulfides with N-alkoxycarbonyl azide as a nitrene precursor was effected by using (OC)Ru(salen) complex 1 as catalyst. The steric and electronic nature of the N-alkoxycarbonyl group was found to strongly affect the enantioselectivity and the reaction rate, and high enantioselectivity (up to 99% ee) and good chemical yields were achieved by using 2,2,2-trichloro-1,1-dimethylethoxycarbonyl azide as the nitrene precursor at room temperature.

Original languageEnglish
Pages (from-to)3301-3303
Number of pages3
JournalTetrahedron Letters
Volume44
Issue number16
DOIs
Publication statusPublished - Apr 14 2003

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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