Highly Enantioselective Reformatsky Reaction of Ketones: Chelation-Assisted Enantioface Discrimination

Akio Ojida, Toru Yamano, Naohiro Taya, Akihiro Tasaka

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

(Matrix Presented) Highly enantioselective Reformatsky reaction of ketones was accomplished using cinchona alkaloids as chiral ligands. Chelation with the sp2-nitrogen adjacent to the reactive carbonyl center contributed the enantioface discrimination for the high enantioselectivities.

Original languageEnglish
Pages (from-to)3051-3054
Number of pages4
JournalOrganic Letters
Volume4
Issue number18
DOIs
Publication statusPublished - Sep 5 2002

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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