Highly enantioselective separation using a supported liquid membrane encapsulating surfactant-enzyme complex

Eijiro Miyako; Tatsuo Maruyama; Noriho Kamiya; Masahiro Goto

doi:10.1021/ja049378d

Highly enantioselective separation using a supported liquid membrane encapsulating surfactant-enzyme complex

Eijiro Miyako, Tatsuo Maruyama, Noriho Kamiya, Masahiro Goto

Applied Chemistry

Research output: Contribution to journal › Article › peer-review

49 Citations (Scopus)

Abstract

We developed a highly enantioselective separation system for the optically active compounds, (S)-ibuprofen and L-phenylalanine, from their racemic mixtures by employing a supported liquid membrane (SLM) encapsulating a surfactant-lipase complex (or a surfactant-α-chymotrypsin complex). In the present system, enzymes encapsulated in the liquid-membrane phase effectively drove the enantioselective transport of optically active compounds through the SLM. This novel SLM allowed high enantioselectivity (ee over 91%) in the optical resolution of racemic ibuprofen and phenylalanine.

Original language	English
Pages (from-to)	8622-8623
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	126
Issue number	28
DOIs	https://doi.org/10.1021/ja049378d
Publication status	Published - Jul 21 2004

All Science Journal Classification (ASJC) codes

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja049378d

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AU - Kamiya, Noriho

AU - Goto, Masahiro

PY - 2004/7/21

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Highly enantioselective separation using a supported liquid membrane encapsulating surfactant-enzyme complex

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