Highly enantioselective separation using a supported liquid membrane encapsulating surfactant-enzyme complex

Eijiro Miyako, Tatsuo Maruyama, Noriho Kamiya, Masahiro Goto

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46 Citations (Scopus)

Abstract

We developed a highly enantioselective separation system for the optically active compounds, (S)-ibuprofen and L-phenylalanine, from their racemic mixtures by employing a supported liquid membrane (SLM) encapsulating a surfactant-lipase complex (or a surfactant-α-chymotrypsin complex). In the present system, enzymes encapsulated in the liquid-membrane phase effectively drove the enantioselective transport of optically active compounds through the SLM. This novel SLM allowed high enantioselectivity (ee over 91%) in the optical resolution of racemic ibuprofen and phenylalanine.

Original languageEnglish
Pages (from-to)8622-8623
Number of pages2
JournalJournal of the American Chemical Society
Volume126
Issue number28
DOIs
Publication statusPublished - Jul 21 2004

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All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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