Highly enantioselective synthesis of organic compound using right- and left-handed helical silica

Itaru Sato, Kousuke Kadowaki, Hiroki Urabe, Jong Hwa Jung, Yoshiyuki Ono, Seiji Shinkai, Kenso Soai

Research output: Contribution to journalArticle

112 Citations (Scopus)

Abstract

Highly enantiomerically enriched (up to 96-97% ee) 5-pyrimidyl alkanol was obtained by the addition of diisopropylzinc to pyrimidine-5-carbaldehyde in the presence of the artificially designed chiral inorganic material, right- and left-handed helical silica.

Original languageEnglish
Pages (from-to)721-724
Number of pages4
JournalTetrahedron Letters
Volume44
Issue number4
DOIs
Publication statusPublished - Jan 20 2003
Externally publishedYes

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Synthetic Chemistry Techniques
Organic compounds
Silicon Dioxide
pyrimidine

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Sato, I., Kadowaki, K., Urabe, H., Jung, J. H., Ono, Y., Shinkai, S., & Soai, K. (2003). Highly enantioselective synthesis of organic compound using right- and left-handed helical silica. Tetrahedron Letters, 44(4), 721-724. https://doi.org/10.1016/S0040-4039(02)02707-7

Highly enantioselective synthesis of organic compound using right- and left-handed helical silica. / Sato, Itaru; Kadowaki, Kousuke; Urabe, Hiroki; Jung, Jong Hwa; Ono, Yoshiyuki; Shinkai, Seiji; Soai, Kenso.

In: Tetrahedron Letters, Vol. 44, No. 4, 20.01.2003, p. 721-724.

Research output: Contribution to journalArticle

Sato, I, Kadowaki, K, Urabe, H, Jung, JH, Ono, Y, Shinkai, S & Soai, K 2003, 'Highly enantioselective synthesis of organic compound using right- and left-handed helical silica', Tetrahedron Letters, vol. 44, no. 4, pp. 721-724. https://doi.org/10.1016/S0040-4039(02)02707-7
Sato, Itaru ; Kadowaki, Kousuke ; Urabe, Hiroki ; Jung, Jong Hwa ; Ono, Yoshiyuki ; Shinkai, Seiji ; Soai, Kenso. / Highly enantioselective synthesis of organic compound using right- and left-handed helical silica. In: Tetrahedron Letters. 2003 ; Vol. 44, No. 4. pp. 721-724.
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