Highly enantioselective synthesis of organic compound using right- and left-handed helical silica

Itaru Sato, Kousuke Kadowaki, Hiroki Urabe, Jong Hwa Jung, Yoshiyuki Ono, Seiji Shinkai, Kenso Soai

Research output: Contribution to journalArticlepeer-review

117 Citations (Scopus)

Abstract

Highly enantiomerically enriched (up to 96-97% ee) 5-pyrimidyl alkanol was obtained by the addition of diisopropylzinc to pyrimidine-5-carbaldehyde in the presence of the artificially designed chiral inorganic material, right- and left-handed helical silica.

Original languageEnglish
Pages (from-to)721-724
Number of pages4
JournalTetrahedron Letters
Volume44
Issue number4
DOIs
Publication statusPublished - Jan 20 2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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