@article{03097331e2ff4c3583d5049fb27aa38d,
title = "Highly malleable haem-binding site of the haemoprotein HasA permits stable accommodation of bulky tetraphenylporphycenes",
abstract = "Iron(iii)- and cobalt(iii)-9,10,19,20-tetraphenylporphycenes, which possess bulky phenyl groups at the four meso positions of porphycene, were successfully incorporated into the haem acquisition protein HasA secreted by Pseudomonas aeruginosa. Crystal structure analysis revealed that loops surrounding the haem-binding site are highly flexible, remodelling themselves to accommodate bulky metal complexes with significantly different structures from the native haem cofactor.",
author = "Erika Sakakibara and Yuma Shisaka and Hiroki Onoda and Daiki Koga and Ning Xu and Toshikazu Ono and Yoshio Hisaeda and Hiroshi Sugimoto and Yoshitsugu Shiro and Yoshihito Watanabe and Osami Shoji",
note = "Funding Information: This work was supported by Grant-in-Aid for Young Scientists (A) from the Ministry of Education, culture, Sports, Science, and Technology to O. S. (26708018) and Core Research for Evolutional Science and Technology, Japan Science and Technology Agency to O. S. (JPMJCR15P3). This work was also supported by KAKENHI, Japan Society for the Promotion of Science (JP15H05806, JP18H02084 and JP18H04265). Publisher Copyright: {\textcopyright} 2019 The Royal Society of Chemistry.",
year = "2019",
doi = "10.1039/c9ra02872b",
language = "English",
volume = "9",
pages = "18697--18702",
journal = "RSC Advances",
issn = "2046-2069",
publisher = "Royal Society of Chemistry",
number = "32",
}