Highly Modified Lanostane Triterpenes from the Wood-Rot Basidiomycete Ganoderma colossus: Comparative Chemical Investigations of Natural and Artificially Cultivated Fruiting Bodies and Mycelial Cultures

Masahiko Isaka, Panida Chinthanom, Rattaket Choeyklin, Tuksaporn Thummarukcharoen, Pranee Rachtawee, Malipan Sappan, Kitlada Srichomthong, Ryoma Fujii, Kyohei Kawashima, Seiji Mori

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2 Citations (Scopus)

Abstract

The wood-rot basidiomycete Ganoderma colossus has been chemically investigated. Comparative analyses of the natural fruiting body, artificially cultivated fruiting bodies, and mycelial cultures resulted in the isolation, in total, of 13 new highly modified lanostanes, ganocolossusins A-H (1-8) and ganodermalactones T-X (9-13), together with 23 known compounds (14-36). There were significant overlaps of the same compounds among the three different states of the fungal materials. Ganocolossusin D (4) displayed the most potent antimalarial activity against Plasmodium falciparum K1 (multi-drug-resistant strain) with an IC50 value of 2.4 μM, while it was noncytotoxic to Vero cells at 50 μg/mL.

Original languageEnglish
Pages (from-to)2066-2075
Number of pages10
JournalJournal of Natural Products
Volume83
Issue number7
DOIs
Publication statusPublished - Jul 24 2020
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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