Hippo vs. Crab

tissue-specific functions of the mammalian Hippo pathway

Miki Nishio, Tomohiko Maehama, Hiroki Goto, Keisuke Nakatani, Wakako Kato, Hirofumi Omori, Yosuke Miyachi, Hideru Togashi, Yohei Shimono, Akira Suzuki

    Research output: Contribution to journalReview article

    6 Citations (Scopus)

    Abstract

    The Hippo signaling pathway is a vital suppressor of tumorigenesis that is often inactivated in human cancers. In normal cells, the Hippo pathway is triggered by external forces such as cell crowding, or changes to the extracellular matrix or cell polarity. Once activated, Hippo signaling down-regulates transcription supported by the paralogous cofactors YAP1 and TAZ. The Hippo pathway's functions in normal and cancer biology have been dissected by studies of mutant mice with null or conditional tissue-specific mutations of Hippo signaling elements. In this review, we attempt to systematically summarize results that have been gleaned from detailed in vivo characterizations of these mutants. Our goal is to describe the physiological roles of Hippo signaling in several normal organ systems, as well as to emphasize how disruption of the Hippo pathway, and particularly hyperactivation of YAP1/TAZ, can be oncogenic.

    Original languageEnglish
    Pages (from-to)6-31
    Number of pages26
    JournalGenes to Cells
    Volume22
    Issue number1
    DOIs
    Publication statusPublished - Jan 1 2017

    Fingerprint

    Cell Polarity
    Crowding
    Extracellular Matrix
    Neoplasms
    Carcinogenesis
    Down-Regulation
    Mutation

    All Science Journal Classification (ASJC) codes

    • Genetics
    • Cell Biology

    Cite this

    Nishio, M., Maehama, T., Goto, H., Nakatani, K., Kato, W., Omori, H., ... Suzuki, A. (2017). Hippo vs. Crab: tissue-specific functions of the mammalian Hippo pathway. Genes to Cells, 22(1), 6-31. https://doi.org/10.1111/gtc.12461

    Hippo vs. Crab : tissue-specific functions of the mammalian Hippo pathway. / Nishio, Miki; Maehama, Tomohiko; Goto, Hiroki; Nakatani, Keisuke; Kato, Wakako; Omori, Hirofumi; Miyachi, Yosuke; Togashi, Hideru; Shimono, Yohei; Suzuki, Akira.

    In: Genes to Cells, Vol. 22, No. 1, 01.01.2017, p. 6-31.

    Research output: Contribution to journalReview article

    Nishio, M, Maehama, T, Goto, H, Nakatani, K, Kato, W, Omori, H, Miyachi, Y, Togashi, H, Shimono, Y & Suzuki, A 2017, 'Hippo vs. Crab: tissue-specific functions of the mammalian Hippo pathway', Genes to Cells, vol. 22, no. 1, pp. 6-31. https://doi.org/10.1111/gtc.12461
    Nishio M, Maehama T, Goto H, Nakatani K, Kato W, Omori H et al. Hippo vs. Crab: tissue-specific functions of the mammalian Hippo pathway. Genes to Cells. 2017 Jan 1;22(1):6-31. https://doi.org/10.1111/gtc.12461
    Nishio, Miki ; Maehama, Tomohiko ; Goto, Hiroki ; Nakatani, Keisuke ; Kato, Wakako ; Omori, Hirofumi ; Miyachi, Yosuke ; Togashi, Hideru ; Shimono, Yohei ; Suzuki, Akira. / Hippo vs. Crab : tissue-specific functions of the mammalian Hippo pathway. In: Genes to Cells. 2017 ; Vol. 22, No. 1. pp. 6-31.
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    AU - Kato, Wakako

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