Histamine increases the Ca current in guinea-pig ventricular myocytes

Ikunobu Muramatsu, Mami Noda, Matomo Nishio, Shigeru Kigoshi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Histamine prolonged the action potential duration and shifted the plateau in an upward direction in guinea-pig ventricular myocytes. Whole cell voltage clamp experiments revealed that histamine increases the amplitude of the inward Ca current with a slight increase in the outward current. Cimetidine but not mepyramine inhibited the effects of histamine. We suggest that histamine increases the Ca current via the mediation of the H2-receptors.

Original languageEnglish
Pages (from-to)269-272
Number of pages4
JournalEuropean Journal of Pharmacology
Volume138
Issue number2
DOIs
Publication statusPublished - Jun 19 1987

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Muscle Cells
Histamine
Guinea Pigs
Pyrilamine
Histamine H2 Receptors
Cimetidine
Action Potentials

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Histamine increases the Ca current in guinea-pig ventricular myocytes. / Muramatsu, Ikunobu; Noda, Mami; Nishio, Matomo; Kigoshi, Shigeru.

In: European Journal of Pharmacology, Vol. 138, No. 2, 19.06.1987, p. 269-272.

Research output: Contribution to journalArticle

Muramatsu, Ikunobu ; Noda, Mami ; Nishio, Matomo ; Kigoshi, Shigeru. / Histamine increases the Ca current in guinea-pig ventricular myocytes. In: European Journal of Pharmacology. 1987 ; Vol. 138, No. 2. pp. 269-272.
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