TY - JOUR
T1 - Histiocytic haemophagocytosis in a patient with Kawasaki disease
T2 - Changes in the hypercytokinaemic state
AU - Ohga, Shouichi
AU - Ooshima, Akio
AU - Fukushige, Junichiro
AU - Ueda, Kohji
PY - 1995/7/1
Y1 - 1995/7/1
N2 - Abstract: A 32-month-old Japanese boy exhibited haemophagocytic syndrome (HPS) during the recurrent course of Kawasaki disease. Despite repeated γ-globulin therapy, he developed cytopenia with marked hepatomegaly and evidence of histiocytic haemophagocytosis in the bone marrow. Serum levels of interferon-γ and tumour necrosis factor, but not of interleukin-1β, increased in parallel with his symptoms. No confirmation was obtained of the association of toxic reactions to the used drugs. No coronary lesions remained as sequelae. Conclusion: Cytopenia in Kawasaki disease could herald HPS, and the hypercytokinaemia involved in the two febrile syndromes might be of distinct nature.
AB - Abstract: A 32-month-old Japanese boy exhibited haemophagocytic syndrome (HPS) during the recurrent course of Kawasaki disease. Despite repeated γ-globulin therapy, he developed cytopenia with marked hepatomegaly and evidence of histiocytic haemophagocytosis in the bone marrow. Serum levels of interferon-γ and tumour necrosis factor, but not of interleukin-1β, increased in parallel with his symptoms. No confirmation was obtained of the association of toxic reactions to the used drugs. No coronary lesions remained as sequelae. Conclusion: Cytopenia in Kawasaki disease could herald HPS, and the hypercytokinaemia involved in the two febrile syndromes might be of distinct nature.
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U2 - 10.1007/BF02074830
DO - 10.1007/BF02074830
M3 - Article
C2 - 7556319
AN - SCOPUS:0029056527
SN - 0340-6199
VL - 154
SP - 539
EP - 541
JO - Acta Paediatrica Hungarica
JF - Acta Paediatrica Hungarica
IS - 7
ER -