Histo-blood group gene polymorphisms as potential genetic modifiers of the development of coronary artery lesions in patients with Kawasaki disease

Kenichiro Yamamura, K. Ihara, K. Ikeda, Hazumu Nagata, Y. Mizuno, T. Hara

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Abnormal immunological responses to certain microbial agents may play a crucial role in the pathogenesis of Kawasaki disease (KD). The association studies between histo-blood group genes (Lewis and ABO blood types) and various types of infectious diseases or vasculopathy have been carried out based on the fact that glycosylated antigens could directly mediate microbial infections. We attempted to clarify the role of blood type antigens in the development of KD and coronary artery lesions in KD patients. The subjects included 164 KD patients enrolled from 1998 to 2003 (1st group), 232 patients from 2004 to 2009 (2nd group), and 223 healthy children and 118 patients with growth hormone deficiency as controls. The genotyping of the FUT2 and FUT3 genes, and ABO genotypes, was determined with the TaqMan SNP assay and allele-specific polymerase chain reaction. No significant differences were observed in the genotypes and allele frequencies of the FUT2 and FUT3 genes between the groups. The frequency of the BB blood genotype was significantly higher in KD patients with coronary artery lesions in the 1st and 2nd groups than in the controls (17% and 14% vs. 5%, P=0.0020). This is the first report to investigate the roles of ABO and Lewis blood types in the development of KD, and in the formation of coronary artery lesions in KD patients. These data suggest that the ABO blood type may play a role in the development of coronary artery lesions in KD patients.

Original languageEnglish
Pages (from-to)119-125
Number of pages7
JournalInternational Journal of Immunogenetics
Volume39
Issue number2
DOIs
Publication statusPublished - Apr 1 2012

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Mucocutaneous Lymph Node Syndrome
Blood Group Antigens
Coronary Vessels
Genes
Genotype
Antigens
Gene Frequency
Growth Hormone
Single Nucleotide Polymorphism
Communicable Diseases
Alleles
Polymerase Chain Reaction
Control Groups
Infection

All Science Journal Classification (ASJC) codes

  • Immunology
  • Molecular Biology
  • Genetics
  • Genetics(clinical)

Cite this

Histo-blood group gene polymorphisms as potential genetic modifiers of the development of coronary artery lesions in patients with Kawasaki disease. / Yamamura, Kenichiro; Ihara, K.; Ikeda, K.; Nagata, Hazumu; Mizuno, Y.; Hara, T.

In: International Journal of Immunogenetics, Vol. 39, No. 2, 01.04.2012, p. 119-125.

Research output: Contribution to journalArticle

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