TY - JOUR
T1 - Histocompatibility Antigens in Primary Biliary Cirrhosis
AU - Kato, Yasuhiro
AU - Kumagai, Mikio
AU - Kobayashi, Kenichi
AU - Hattori, Nobu
AU - Sasazuki, Tatehiko
PY - 1982/5
Y1 - 1982/5
N2 - Primary biliary cirrhosis (PBC) is characterized by marked perturbation of the immune system. In addition, there are familial associations which suggest genetic background to the disease. We have studied HLA‐A, B, and D loci in 15 Japanese women with PBC, and compared them to controls. Although HLA‐A and B loci in PBC patients showed similar prevalence to the control population, HLA‐DHO was significantly more common, occurring in 69% of patients with PBC and 21% of controls. This suggests a genetic predisposition to PBC, and the HLA‐DHO locus association may reflect a genetic abnormality of the immune responses.
AB - Primary biliary cirrhosis (PBC) is characterized by marked perturbation of the immune system. In addition, there are familial associations which suggest genetic background to the disease. We have studied HLA‐A, B, and D loci in 15 Japanese women with PBC, and compared them to controls. Although HLA‐A and B loci in PBC patients showed similar prevalence to the control population, HLA‐DHO was significantly more common, occurring in 69% of patients with PBC and 21% of controls. This suggests a genetic predisposition to PBC, and the HLA‐DHO locus association may reflect a genetic abnormality of the immune responses.
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U2 - 10.1111/j.1572-0241.1982.tb04774.x
DO - 10.1111/j.1572-0241.1982.tb04774.x
M3 - Article
C2 - 6952761
AN - SCOPUS:0020071252
SN - 0002-9270
VL - 77
SP - 312
EP - 313
JO - American Journal of Gastroenterology
JF - American Journal of Gastroenterology
IS - 5
ER -