Histogenesis of intralesional fibrous septum in chordoma

Takahiko Naka, Carsten Boltze, Doerthe Kuester, Amir Samii, Christian Herold, Helmut Ostertag, Yukihide Iwamoto, Yoshinao Oda, Masazumi Tsuneyoshi, Albert Roessner

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Intralesional fibrous septum (IFS), a histologic architecture that is typical of chordoma, consists of proliferating spindle-shaped, fibroblast-like cells with an abundance of collagen fibers. However, the histogenesis of IFS is still controversial. In a series of 122 chordomas, special emphasis was placed on the morphology of host tissues involved in IFS and on a transition between IFS and neighboring tissues. In 23 lesions, IFS was also characterized both histochemically and immunohistochemically. IFS was observed in 79 (64.8%) lesions. Occasionally, IFS contained bone fragments and hyalinized matrix with no lining of osteoblastic cells, suggesting degenerated rather than metaplastic bone tissue. Moreover, IFS occasionally showed a direct transition to host bone trabeculae. Histochemically and immunohistochemically, IFS included calcium deposits positive for Alizarin red S staining and expressed both type I and type III collagen. In extraosseous lesions extending to the adjacent soft tissues, IFS frequently involved muscle fibers or peripheral nerve fibers and displayed a smooth transition to neighboring soft tissues. We believe that IFS is induced by a tumor-host interaction that is based on the host bone trabeculae in intraosseous lesions or on soft tissues in extraosseous lesions.

Original languageEnglish
Pages (from-to)443-447
Number of pages5
JournalPathology Research and Practice
Volume201
Issue number6
DOIs
Publication statusPublished - Aug 24 2005

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Cell Biology

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  • Cite this

    Naka, T., Boltze, C., Kuester, D., Samii, A., Herold, C., Ostertag, H., Iwamoto, Y., Oda, Y., Tsuneyoshi, M., & Roessner, A. (2005). Histogenesis of intralesional fibrous septum in chordoma. Pathology Research and Practice, 201(6), 443-447. https://doi.org/10.1016/j.prp.2005.05.007