Histologic differentiation and chemosensitivity of human head and neck squamous cell carcinomas

Tadashi Nakashima, Yoshihiko Maehara, Shunji Kohnoe, Itsuroh Hayashi, Yasaburoh Katsuta

Research output: Contribution to journalArticle

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Abstract

The chemosensitivities of 42 human head and neck squamous cell carcinomas were examined using the in vitro succinate dehydrogenase inhibition (SDI) test. The tumor tissues obtained at surgery or biopsy were exposed to five different antitumor drugs: adriamycin (ADM), cisplatin (CDDP), carboquone (CQ), 5‐fluorouracil (5‐FU), and 1‐hexylcarbamoyl‐5‐fluorouracil (HCFU). The results were analyzed according to the histopathologic degree of differentiation of well, moderately, and poorly differentiated squamous cell carcinoma. The average decrease in succinate dehydrogenase activity was 43.2 /pm 24.9 for ADM, 29.0 /pm 14.2 for CDDP, 32.9 /pm 17.6 for CQ, 64.2 /pm 20.6 for 5‐FU, and 26.8 /pm 16.9 for HCFU. There was a statistically significant difference in the decrease of succinate dehydrogenase activity between well and poorly differentiated squamous cell carcinomas. These data suggest that, for patients with a poorly differentiated squamous cell carcinoma, the response to anticancer drugs may be more satisfactory than in those with a welldifferentiated squamous cell carcinoma.

Original languageEnglish
Pages (from-to)406-410
Number of pages5
JournalHead & Neck
Volume12
Issue number5
DOIs
Publication statusPublished - Jan 1 1990

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Succinate Dehydrogenase
Squamous Cell Carcinoma
Carbazilquinone
Doxorubicin
Antineoplastic Agents
Cisplatin
Biopsy
Carcinoma, squamous cell of head and neck
Pharmaceutical Preparations
Neoplasms
1-hexylcarbamoyl-5-fluorouracil

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

Cite this

Histologic differentiation and chemosensitivity of human head and neck squamous cell carcinomas. / Nakashima, Tadashi; Maehara, Yoshihiko; Kohnoe, Shunji; Hayashi, Itsuroh; Katsuta, Yasaburoh.

In: Head & Neck, Vol. 12, No. 5, 01.01.1990, p. 406-410.

Research output: Contribution to journalArticle

Nakashima, T, Maehara, Y, Kohnoe, S, Hayashi, I & Katsuta, Y 1990, 'Histologic differentiation and chemosensitivity of human head and neck squamous cell carcinomas', Head & Neck, vol. 12, no. 5, pp. 406-410. https://doi.org/10.1002/hed.2880120506
Nakashima, Tadashi ; Maehara, Yoshihiko ; Kohnoe, Shunji ; Hayashi, Itsuroh ; Katsuta, Yasaburoh. / Histologic differentiation and chemosensitivity of human head and neck squamous cell carcinomas. In: Head & Neck. 1990 ; Vol. 12, No. 5. pp. 406-410.
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