Histological and biological characteristics of esophageal dysplasia

Eiji Oki, Masayuki Watanabe, Masahiko Ikebe, Masaru Morita, Motonori Futatsugi, Yoshihiro Kakeji, Hideo Baba, Yoshihiko Maehara

Research output: Contribution to journalArticle

Abstract

Dysplasia is an important problem in esophageal carcinogenesis, and there are controversial opinions concerning whether esophageal squamous dysplasia is a cancerous lesion. In the present study, it was histopathologically and biologically confirmed that dysplasia has a close correlation with cancer. Dysplasia was frequently observed with early stages of carcinoma. Although continuity of dysplastic lesions into the carcinoma area is not frequently observed, this continuity is observed in severe dysplasia more often than in mild or moderate dysplasia. The proliferating cell nuclear antigen labeling index (PCNA LI) showed no substantial difference in the cell proliferative activities of dysplasia and intraepithelial carcinoma. In addition, p53 immunohistochemical analysis revealed that p53 positivities in carcinomas and dysplasias were contiguous to each other. These findings indicate that the relationship between the severity of dysplasia and carcinoma has high potential for leading to malignancy. Therefore, dysplasias can be treated as early cancerous lesions of the esophagus to prevent serious results.

Original languageEnglish
Pages (from-to)129-132
Number of pages4
JournalEsophagus
Volume2
Issue number3
DOIs
Publication statusPublished - Sep 1 2005

Fingerprint

Carcinoma
Carcinoma in Situ
Proliferating Cell Nuclear Antigen
Esophagus
Neoplasms
Carcinogenesis

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Oki, E., Watanabe, M., Ikebe, M., Morita, M., Futatsugi, M., Kakeji, Y., ... Maehara, Y. (2005). Histological and biological characteristics of esophageal dysplasia. Esophagus, 2(3), 129-132. https://doi.org/10.1007/s10388-005-0050-8

Histological and biological characteristics of esophageal dysplasia. / Oki, Eiji; Watanabe, Masayuki; Ikebe, Masahiko; Morita, Masaru; Futatsugi, Motonori; Kakeji, Yoshihiro; Baba, Hideo; Maehara, Yoshihiko.

In: Esophagus, Vol. 2, No. 3, 01.09.2005, p. 129-132.

Research output: Contribution to journalArticle

Oki, E, Watanabe, M, Ikebe, M, Morita, M, Futatsugi, M, Kakeji, Y, Baba, H & Maehara, Y 2005, 'Histological and biological characteristics of esophageal dysplasia', Esophagus, vol. 2, no. 3, pp. 129-132. https://doi.org/10.1007/s10388-005-0050-8
Oki E, Watanabe M, Ikebe M, Morita M, Futatsugi M, Kakeji Y et al. Histological and biological characteristics of esophageal dysplasia. Esophagus. 2005 Sep 1;2(3):129-132. https://doi.org/10.1007/s10388-005-0050-8
Oki, Eiji ; Watanabe, Masayuki ; Ikebe, Masahiko ; Morita, Masaru ; Futatsugi, Motonori ; Kakeji, Yoshihiro ; Baba, Hideo ; Maehara, Yoshihiko. / Histological and biological characteristics of esophageal dysplasia. In: Esophagus. 2005 ; Vol. 2, No. 3. pp. 129-132.
@article{f467f84efe7944ab90be4e6e9a6dd7c2,
title = "Histological and biological characteristics of esophageal dysplasia",
abstract = "Dysplasia is an important problem in esophageal carcinogenesis, and there are controversial opinions concerning whether esophageal squamous dysplasia is a cancerous lesion. In the present study, it was histopathologically and biologically confirmed that dysplasia has a close correlation with cancer. Dysplasia was frequently observed with early stages of carcinoma. Although continuity of dysplastic lesions into the carcinoma area is not frequently observed, this continuity is observed in severe dysplasia more often than in mild or moderate dysplasia. The proliferating cell nuclear antigen labeling index (PCNA LI) showed no substantial difference in the cell proliferative activities of dysplasia and intraepithelial carcinoma. In addition, p53 immunohistochemical analysis revealed that p53 positivities in carcinomas and dysplasias were contiguous to each other. These findings indicate that the relationship between the severity of dysplasia and carcinoma has high potential for leading to malignancy. Therefore, dysplasias can be treated as early cancerous lesions of the esophagus to prevent serious results.",
author = "Eiji Oki and Masayuki Watanabe and Masahiko Ikebe and Masaru Morita and Motonori Futatsugi and Yoshihiro Kakeji and Hideo Baba and Yoshihiko Maehara",
year = "2005",
month = "9",
day = "1",
doi = "10.1007/s10388-005-0050-8",
language = "English",
volume = "2",
pages = "129--132",
journal = "Esophagus",
issn = "1612-9059",
publisher = "Springer Japan",
number = "3",

}

TY - JOUR

T1 - Histological and biological characteristics of esophageal dysplasia

AU - Oki, Eiji

AU - Watanabe, Masayuki

AU - Ikebe, Masahiko

AU - Morita, Masaru

AU - Futatsugi, Motonori

AU - Kakeji, Yoshihiro

AU - Baba, Hideo

AU - Maehara, Yoshihiko

PY - 2005/9/1

Y1 - 2005/9/1

N2 - Dysplasia is an important problem in esophageal carcinogenesis, and there are controversial opinions concerning whether esophageal squamous dysplasia is a cancerous lesion. In the present study, it was histopathologically and biologically confirmed that dysplasia has a close correlation with cancer. Dysplasia was frequently observed with early stages of carcinoma. Although continuity of dysplastic lesions into the carcinoma area is not frequently observed, this continuity is observed in severe dysplasia more often than in mild or moderate dysplasia. The proliferating cell nuclear antigen labeling index (PCNA LI) showed no substantial difference in the cell proliferative activities of dysplasia and intraepithelial carcinoma. In addition, p53 immunohistochemical analysis revealed that p53 positivities in carcinomas and dysplasias were contiguous to each other. These findings indicate that the relationship between the severity of dysplasia and carcinoma has high potential for leading to malignancy. Therefore, dysplasias can be treated as early cancerous lesions of the esophagus to prevent serious results.

AB - Dysplasia is an important problem in esophageal carcinogenesis, and there are controversial opinions concerning whether esophageal squamous dysplasia is a cancerous lesion. In the present study, it was histopathologically and biologically confirmed that dysplasia has a close correlation with cancer. Dysplasia was frequently observed with early stages of carcinoma. Although continuity of dysplastic lesions into the carcinoma area is not frequently observed, this continuity is observed in severe dysplasia more often than in mild or moderate dysplasia. The proliferating cell nuclear antigen labeling index (PCNA LI) showed no substantial difference in the cell proliferative activities of dysplasia and intraepithelial carcinoma. In addition, p53 immunohistochemical analysis revealed that p53 positivities in carcinomas and dysplasias were contiguous to each other. These findings indicate that the relationship between the severity of dysplasia and carcinoma has high potential for leading to malignancy. Therefore, dysplasias can be treated as early cancerous lesions of the esophagus to prevent serious results.

UR - http://www.scopus.com/inward/record.url?scp=25444498577&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=25444498577&partnerID=8YFLogxK

U2 - 10.1007/s10388-005-0050-8

DO - 10.1007/s10388-005-0050-8

M3 - Article

AN - SCOPUS:25444498577

VL - 2

SP - 129

EP - 132

JO - Esophagus

JF - Esophagus

SN - 1612-9059

IS - 3

ER -