Histological architectural classification determines recurrence pattern and prognosis after curative hepatectomy in patients with hepatocellular carcinoma

Hirohisa Okabe, Tomoharu Yoshizumi, Yo Ichi Yamashita, Katsunori Imai, Hiromitsu Hayashi, Shigeki Nakagawa, Shinji Itoh, Norifumi Harimoto, Toru Ikegami, Hideaki Uchiyama, Toru Beppu, Shinichi Aishima, Ken Shirabe, Hideo Baba, Yoshihiko Maehara

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Aim The clinical impact of pathological classification based on architectural pattern in hepatocellular carcinoma (HCC) remains elusive in spite of its well-known and common feature. Methods The prognostic impact of pathological classification was examined with prospective database. Three hundred and eighty HCC patients who underwent curative hepatectomy as an initial treatment in Kumamoto University were enrolled as a test cohort. The outcome was confirmed with a validation cohort in Kyushu University. Results Macrotrabecular (macro-T) subtype (n = 38) and compact subtype (n = 43) showed similar biological and prognostic features. Both showed higher AFP level and worse overall survival than microrabecular (micro-T) subtype (n = 266). Multivariate analysis for overall survival revealed that DCP 40, multiple tumor and macro-T/compact subtype were associated with poor overall survival (risk ratio = 2.2, 1.6 and 1.6; p = 0.002, 0.020, and 0.047, respectively). Of note, 32% of macro-T/compact subtype showed early recurrence within 1 year, which showed substantially low (5%) 5 year overall survival, whereas 16% of micro-T/PG subtype did. Twenty-one percent of macro-T/compact subtype showed multiple intrahepatic metastases ( 4) or distant metastases, which resulted in non-curative treatment, whereas 5% of micro-T/PG subtype did. In validation cohort, macro-T/compact subtype was an independent predictor of worse overall survival. Conclusion Macro-T/compact subtype is biologically discriminated from micro-T and PG subtypes due to its aggressive features and poor prognosis after curative treatment. Additional treatment with curative hepatectomy on Macro-T/compact subtype should be discussed because of high possibility of systemic residual cancer cell.

Original languageEnglish
Article numbere0203856
JournalPloS one
Volume13
Issue number9
DOIs
Publication statusPublished - Sep 2018

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Hepatectomy
hepatoma
metastasis
prognosis
Macros
Hepatocellular Carcinoma
Recurrence
Survival
relative risk
multivariate analysis
Tumors
Cells
Japan
neoplasms
Neoplasm Metastasis
Residual Neoplasm
Therapeutics
testing
Multivariate Analysis
Odds Ratio

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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Histological architectural classification determines recurrence pattern and prognosis after curative hepatectomy in patients with hepatocellular carcinoma. / Okabe, Hirohisa; Yoshizumi, Tomoharu; Yamashita, Yo Ichi; Imai, Katsunori; Hayashi, Hiromitsu; Nakagawa, Shigeki; Itoh, Shinji; Harimoto, Norifumi; Ikegami, Toru; Uchiyama, Hideaki; Beppu, Toru; Aishima, Shinichi; Shirabe, Ken; Baba, Hideo; Maehara, Yoshihiko.

In: PloS one, Vol. 13, No. 9, e0203856, 09.2018.

Research output: Contribution to journalArticle

Okabe, H, Yoshizumi, T, Yamashita, YI, Imai, K, Hayashi, H, Nakagawa, S, Itoh, S, Harimoto, N, Ikegami, T, Uchiyama, H, Beppu, T, Aishima, S, Shirabe, K, Baba, H & Maehara, Y 2018, 'Histological architectural classification determines recurrence pattern and prognosis after curative hepatectomy in patients with hepatocellular carcinoma', PloS one, vol. 13, no. 9, e0203856. https://doi.org/10.1371/journal.pone.0203856
Okabe, Hirohisa ; Yoshizumi, Tomoharu ; Yamashita, Yo Ichi ; Imai, Katsunori ; Hayashi, Hiromitsu ; Nakagawa, Shigeki ; Itoh, Shinji ; Harimoto, Norifumi ; Ikegami, Toru ; Uchiyama, Hideaki ; Beppu, Toru ; Aishima, Shinichi ; Shirabe, Ken ; Baba, Hideo ; Maehara, Yoshihiko. / Histological architectural classification determines recurrence pattern and prognosis after curative hepatectomy in patients with hepatocellular carcinoma. In: PloS one. 2018 ; Vol. 13, No. 9.
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abstract = "Aim The clinical impact of pathological classification based on architectural pattern in hepatocellular carcinoma (HCC) remains elusive in spite of its well-known and common feature. Methods The prognostic impact of pathological classification was examined with prospective database. Three hundred and eighty HCC patients who underwent curative hepatectomy as an initial treatment in Kumamoto University were enrolled as a test cohort. The outcome was confirmed with a validation cohort in Kyushu University. Results Macrotrabecular (macro-T) subtype (n = 38) and compact subtype (n = 43) showed similar biological and prognostic features. Both showed higher AFP level and worse overall survival than microrabecular (micro-T) subtype (n = 266). Multivariate analysis for overall survival revealed that DCP 40, multiple tumor and macro-T/compact subtype were associated with poor overall survival (risk ratio = 2.2, 1.6 and 1.6; p = 0.002, 0.020, and 0.047, respectively). Of note, 32{\%} of macro-T/compact subtype showed early recurrence within 1 year, which showed substantially low (5{\%}) 5 year overall survival, whereas 16{\%} of micro-T/PG subtype did. Twenty-one percent of macro-T/compact subtype showed multiple intrahepatic metastases ( 4) or distant metastases, which resulted in non-curative treatment, whereas 5{\%} of micro-T/PG subtype did. In validation cohort, macro-T/compact subtype was an independent predictor of worse overall survival. Conclusion Macro-T/compact subtype is biologically discriminated from micro-T and PG subtypes due to its aggressive features and poor prognosis after curative treatment. Additional treatment with curative hepatectomy on Macro-T/compact subtype should be discussed because of high possibility of systemic residual cancer cell.",
author = "Hirohisa Okabe and Tomoharu Yoshizumi and Yamashita, {Yo Ichi} and Katsunori Imai and Hiromitsu Hayashi and Shigeki Nakagawa and Shinji Itoh and Norifumi Harimoto and Toru Ikegami and Hideaki Uchiyama and Toru Beppu and Shinichi Aishima and Ken Shirabe and Hideo Baba and Yoshihiko Maehara",
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T1 - Histological architectural classification determines recurrence pattern and prognosis after curative hepatectomy in patients with hepatocellular carcinoma

AU - Okabe, Hirohisa

AU - Yoshizumi, Tomoharu

AU - Yamashita, Yo Ichi

AU - Imai, Katsunori

AU - Hayashi, Hiromitsu

AU - Nakagawa, Shigeki

AU - Itoh, Shinji

AU - Harimoto, Norifumi

AU - Ikegami, Toru

AU - Uchiyama, Hideaki

AU - Beppu, Toru

AU - Aishima, Shinichi

AU - Shirabe, Ken

AU - Baba, Hideo

AU - Maehara, Yoshihiko

PY - 2018/9

Y1 - 2018/9

N2 - Aim The clinical impact of pathological classification based on architectural pattern in hepatocellular carcinoma (HCC) remains elusive in spite of its well-known and common feature. Methods The prognostic impact of pathological classification was examined with prospective database. Three hundred and eighty HCC patients who underwent curative hepatectomy as an initial treatment in Kumamoto University were enrolled as a test cohort. The outcome was confirmed with a validation cohort in Kyushu University. Results Macrotrabecular (macro-T) subtype (n = 38) and compact subtype (n = 43) showed similar biological and prognostic features. Both showed higher AFP level and worse overall survival than microrabecular (micro-T) subtype (n = 266). Multivariate analysis for overall survival revealed that DCP 40, multiple tumor and macro-T/compact subtype were associated with poor overall survival (risk ratio = 2.2, 1.6 and 1.6; p = 0.002, 0.020, and 0.047, respectively). Of note, 32% of macro-T/compact subtype showed early recurrence within 1 year, which showed substantially low (5%) 5 year overall survival, whereas 16% of micro-T/PG subtype did. Twenty-one percent of macro-T/compact subtype showed multiple intrahepatic metastases ( 4) or distant metastases, which resulted in non-curative treatment, whereas 5% of micro-T/PG subtype did. In validation cohort, macro-T/compact subtype was an independent predictor of worse overall survival. Conclusion Macro-T/compact subtype is biologically discriminated from micro-T and PG subtypes due to its aggressive features and poor prognosis after curative treatment. Additional treatment with curative hepatectomy on Macro-T/compact subtype should be discussed because of high possibility of systemic residual cancer cell.

AB - Aim The clinical impact of pathological classification based on architectural pattern in hepatocellular carcinoma (HCC) remains elusive in spite of its well-known and common feature. Methods The prognostic impact of pathological classification was examined with prospective database. Three hundred and eighty HCC patients who underwent curative hepatectomy as an initial treatment in Kumamoto University were enrolled as a test cohort. The outcome was confirmed with a validation cohort in Kyushu University. Results Macrotrabecular (macro-T) subtype (n = 38) and compact subtype (n = 43) showed similar biological and prognostic features. Both showed higher AFP level and worse overall survival than microrabecular (micro-T) subtype (n = 266). Multivariate analysis for overall survival revealed that DCP 40, multiple tumor and macro-T/compact subtype were associated with poor overall survival (risk ratio = 2.2, 1.6 and 1.6; p = 0.002, 0.020, and 0.047, respectively). Of note, 32% of macro-T/compact subtype showed early recurrence within 1 year, which showed substantially low (5%) 5 year overall survival, whereas 16% of micro-T/PG subtype did. Twenty-one percent of macro-T/compact subtype showed multiple intrahepatic metastases ( 4) or distant metastases, which resulted in non-curative treatment, whereas 5% of micro-T/PG subtype did. In validation cohort, macro-T/compact subtype was an independent predictor of worse overall survival. Conclusion Macro-T/compact subtype is biologically discriminated from micro-T and PG subtypes due to its aggressive features and poor prognosis after curative treatment. Additional treatment with curative hepatectomy on Macro-T/compact subtype should be discussed because of high possibility of systemic residual cancer cell.

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