Abstract
The International Union Against Cancer (UICC) does not define the number of sections required from each regional lymph node to record pTNM classification. This study was designed to clarify the incidence of occult metastasis and to assess the pN upgrading of patients with oral cancer. Ultimately, this study led to a proposal for appropriate semiserial sectioning guidelines. Five hundred fifty-four nonmetastatic cervical lymph nodes taken from 73 patients with oral cancer were subjected to hematoxylin-eosin (HE) staining and keratin immunohistochemistry. Micrometastases, defined as foci ≤ 3 mm, were detected in 29 sites of 23 lymph nodes (4.2%) of 16 patients (21.9%). In 9 patients (12.3%) pN upgrading was needed: in 6 from pN0 to pN1, in 1 from pN0 to pN2b, and in 2 from pN1 to pN2b. The remaining 13 lymph nodes with occult metastasis were found in 5 pN2b and 2 pN2c patients, resulting in no pN upgrading. Occult metastasis was also detected in 6 small lymph nodes 5 mm in diameter. The average minor axis of the micrometastasis was 1.36 ± 0.85 mm. We propose that the lymph nodes should be cut and examined at 1-mm intervals to detect micrometastatic foci and to evaluate the pN classification accurately.
| Original language | English |
|---|---|
| Pages (from-to) | 116-121 |
| Number of pages | 6 |
| Journal | Virchows Archiv |
| Volume | 437 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jan 1 2000 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Pathology and Forensic Medicine
- Molecular Biology
- Cell Biology
Cite this
Histological study on pN upgrading of oral cancer. / Hamakawa, Hiroyuki; Takemura, Kota; Sumida, Tomoki; Kayahara, Hiroaki; Tanioka, Hiroaki; Sogawa, Kenichi.
In: Virchows Archiv, Vol. 437, No. 2, 01.01.2000, p. 116-121.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Histological study on pN upgrading of oral cancer
AU - Hamakawa, Hiroyuki
AU - Takemura, Kota
AU - Sumida, Tomoki
AU - Kayahara, Hiroaki
AU - Tanioka, Hiroaki
AU - Sogawa, Kenichi
PY - 2000/1/1
Y1 - 2000/1/1
N2 - The International Union Against Cancer (UICC) does not define the number of sections required from each regional lymph node to record pTNM classification. This study was designed to clarify the incidence of occult metastasis and to assess the pN upgrading of patients with oral cancer. Ultimately, this study led to a proposal for appropriate semiserial sectioning guidelines. Five hundred fifty-four nonmetastatic cervical lymph nodes taken from 73 patients with oral cancer were subjected to hematoxylin-eosin (HE) staining and keratin immunohistochemistry. Micrometastases, defined as foci ≤ 3 mm, were detected in 29 sites of 23 lymph nodes (4.2%) of 16 patients (21.9%). In 9 patients (12.3%) pN upgrading was needed: in 6 from pN0 to pN1, in 1 from pN0 to pN2b, and in 2 from pN1 to pN2b. The remaining 13 lymph nodes with occult metastasis were found in 5 pN2b and 2 pN2c patients, resulting in no pN upgrading. Occult metastasis was also detected in 6 small lymph nodes 5 mm in diameter. The average minor axis of the micrometastasis was 1.36 ± 0.85 mm. We propose that the lymph nodes should be cut and examined at 1-mm intervals to detect micrometastatic foci and to evaluate the pN classification accurately.
AB - The International Union Against Cancer (UICC) does not define the number of sections required from each regional lymph node to record pTNM classification. This study was designed to clarify the incidence of occult metastasis and to assess the pN upgrading of patients with oral cancer. Ultimately, this study led to a proposal for appropriate semiserial sectioning guidelines. Five hundred fifty-four nonmetastatic cervical lymph nodes taken from 73 patients with oral cancer were subjected to hematoxylin-eosin (HE) staining and keratin immunohistochemistry. Micrometastases, defined as foci ≤ 3 mm, were detected in 29 sites of 23 lymph nodes (4.2%) of 16 patients (21.9%). In 9 patients (12.3%) pN upgrading was needed: in 6 from pN0 to pN1, in 1 from pN0 to pN2b, and in 2 from pN1 to pN2b. The remaining 13 lymph nodes with occult metastasis were found in 5 pN2b and 2 pN2c patients, resulting in no pN upgrading. Occult metastasis was also detected in 6 small lymph nodes 5 mm in diameter. The average minor axis of the micrometastasis was 1.36 ± 0.85 mm. We propose that the lymph nodes should be cut and examined at 1-mm intervals to detect micrometastatic foci and to evaluate the pN classification accurately.
UR - http://www.scopus.com/inward/record.url?scp=0033869932&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033869932&partnerID=8YFLogxK
U2 - 10.1007/s004280000199
DO - 10.1007/s004280000199
M3 - Article
C2 - 10993270
AN - SCOPUS:0033869932
VL - 437
SP - 116
EP - 121
JO - Virchows Archiv
JF - Virchows Archiv
SN - 0945-6317
IS - 2
ER -