Histological study on pN upgrading of oral cancer

Hiroyuki Hamakawa, Kota Takemura, Tomoki Sumida, Hiroaki Kayahara, Hiroaki Tanioka, Kenichi Sogawa

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

The International Union Against Cancer (UICC) does not define the number of sections required from each regional lymph node to record pTNM classification. This study was designed to clarify the incidence of occult metastasis and to assess the pN upgrading of patients with oral cancer. Ultimately, this study led to a proposal for appropriate semiserial sectioning guidelines. Five hundred fifty-four nonmetastatic cervical lymph nodes taken from 73 patients with oral cancer were subjected to hematoxylin-eosin (HE) staining and keratin immunohistochemistry. Micrometastases, defined as foci ≤ 3 mm, were detected in 29 sites of 23 lymph nodes (4.2%) of 16 patients (21.9%). In 9 patients (12.3%) pN upgrading was needed: in 6 from pN0 to pN1, in 1 from pN0 to pN2b, and in 2 from pN1 to pN2b. The remaining 13 lymph nodes with occult metastasis were found in 5 pN2b and 2 pN2c patients, resulting in no pN upgrading. Occult metastasis was also detected in 6 small lymph nodes 5 mm in diameter. The average minor axis of the micrometastasis was 1.36 ± 0.85 mm. We propose that the lymph nodes should be cut and examined at 1-mm intervals to detect micrometastatic foci and to evaluate the pN classification accurately.

Original languageEnglish
Pages (from-to)116-121
Number of pages6
JournalVirchows Archiv
Volume437
Issue number2
DOIs
Publication statusPublished - Jan 1 2000
Externally publishedYes

Fingerprint

Mouth Neoplasms
Lymph Nodes
Neoplasm Micrometastasis
Neoplasm Metastasis
Hematoxylin
Eosine Yellowish-(YS)
Keratins
Immunohistochemistry
Guidelines
Staining and Labeling
Incidence

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

Cite this

Hamakawa, H., Takemura, K., Sumida, T., Kayahara, H., Tanioka, H., & Sogawa, K. (2000). Histological study on pN upgrading of oral cancer. Virchows Archiv, 437(2), 116-121. https://doi.org/10.1007/s004280000199

Histological study on pN upgrading of oral cancer. / Hamakawa, Hiroyuki; Takemura, Kota; Sumida, Tomoki; Kayahara, Hiroaki; Tanioka, Hiroaki; Sogawa, Kenichi.

In: Virchows Archiv, Vol. 437, No. 2, 01.01.2000, p. 116-121.

Research output: Contribution to journalArticle

Hamakawa, H, Takemura, K, Sumida, T, Kayahara, H, Tanioka, H & Sogawa, K 2000, 'Histological study on pN upgrading of oral cancer', Virchows Archiv, vol. 437, no. 2, pp. 116-121. https://doi.org/10.1007/s004280000199
Hamakawa H, Takemura K, Sumida T, Kayahara H, Tanioka H, Sogawa K. Histological study on pN upgrading of oral cancer. Virchows Archiv. 2000 Jan 1;437(2):116-121. https://doi.org/10.1007/s004280000199
Hamakawa, Hiroyuki ; Takemura, Kota ; Sumida, Tomoki ; Kayahara, Hiroaki ; Tanioka, Hiroaki ; Sogawa, Kenichi. / Histological study on pN upgrading of oral cancer. In: Virchows Archiv. 2000 ; Vol. 437, No. 2. pp. 116-121.
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