Histological suggestions of 'paratransformation' in oesophageal squamous cell carcinoma

Hiroyuki Kuwano; Kohei Sumiyoshi; Mitsuhiro Yasuda; Tadahiro Nozoe; Masayuki Watanabe; Shinji Ohno; Keizo Sugimachi

doi:10.1016/S0748-7983(95)97231-5

Histological suggestions of 'paratransformation' in oesophageal squamous cell carcinoma

Hiroyuki Kuwano, Kohei Sumiyoshi, Mitsuhiro Yasuda, Tadahiro Nozoe, Masayuki Watanabe, Shinji Ohno, Keizo Sugimachi

Faculty of Medical Sciences

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

We have postulated that oesophageal squamous cell carcinoma arises from multifocal areas and not from one cell, and we present the circumstantial evidence for field carcinogenesis in oesophageal cancer. Among 290 cases examined with oesophageal squamous cell carcinoma, lymphatic permeation or intramural metastasis was evident in 110 cases. Of these carcinomatous transformation of the epithelium adjacent to either lymphatic vessel permeation or intramural metastasis of the squamous cell carcinoma was recognized in six cases. It is considered that the cancer tissue either in the lymphatic vessel or intramural metastasis promotes a malignant transformation of the squamous epithelium over these foci. 'Paratransformation' is therefore thought to be one of the potential models of origin for oesophageal squamous cell carcinoma.

Original language	English
Pages (from-to)	541-544
Number of pages	4
Journal	European Journal of Surgical Oncology
Volume	21
Issue number	5
DOIs	https://doi.org/10.1016/S0748-7983(95)97231-5
Publication status	Published - Oct 1995

All Science Journal Classification (ASJC) codes

Surgery
Oncology

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title = "Histological suggestions of 'paratransformation' in oesophageal squamous cell carcinoma",

abstract = "We have postulated that oesophageal squamous cell carcinoma arises from multifocal areas and not from one cell, and we present the circumstantial evidence for field carcinogenesis in oesophageal cancer. Among 290 cases examined with oesophageal squamous cell carcinoma, lymphatic permeation or intramural metastasis was evident in 110 cases. Of these carcinomatous transformation of the epithelium adjacent to either lymphatic vessel permeation or intramural metastasis of the squamous cell carcinoma was recognized in six cases. It is considered that the cancer tissue either in the lymphatic vessel or intramural metastasis promotes a malignant transformation of the squamous epithelium over these foci. 'Paratransformation' is therefore thought to be one of the potential models of origin for oesophageal squamous cell carcinoma.",

author = "Hiroyuki Kuwano and Kohei Sumiyoshi and Mitsuhiro Yasuda and Tadahiro Nozoe and Masayuki Watanabe and Shinji Ohno and Keizo Sugimachi",

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T1 - Histological suggestions of 'paratransformation' in oesophageal squamous cell carcinoma

AU - Kuwano, Hiroyuki

AU - Sumiyoshi, Kohei

AU - Yasuda, Mitsuhiro

AU - Nozoe, Tadahiro

AU - Watanabe, Masayuki

AU - Ohno, Shinji

AU - Sugimachi, Keizo

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N2 - We have postulated that oesophageal squamous cell carcinoma arises from multifocal areas and not from one cell, and we present the circumstantial evidence for field carcinogenesis in oesophageal cancer. Among 290 cases examined with oesophageal squamous cell carcinoma, lymphatic permeation or intramural metastasis was evident in 110 cases. Of these carcinomatous transformation of the epithelium adjacent to either lymphatic vessel permeation or intramural metastasis of the squamous cell carcinoma was recognized in six cases. It is considered that the cancer tissue either in the lymphatic vessel or intramural metastasis promotes a malignant transformation of the squamous epithelium over these foci. 'Paratransformation' is therefore thought to be one of the potential models of origin for oesophageal squamous cell carcinoma.

AB - We have postulated that oesophageal squamous cell carcinoma arises from multifocal areas and not from one cell, and we present the circumstantial evidence for field carcinogenesis in oesophageal cancer. Among 290 cases examined with oesophageal squamous cell carcinoma, lymphatic permeation or intramural metastasis was evident in 110 cases. Of these carcinomatous transformation of the epithelium adjacent to either lymphatic vessel permeation or intramural metastasis of the squamous cell carcinoma was recognized in six cases. It is considered that the cancer tissue either in the lymphatic vessel or intramural metastasis promotes a malignant transformation of the squamous epithelium over these foci. 'Paratransformation' is therefore thought to be one of the potential models of origin for oesophageal squamous cell carcinoma.

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