TY - JOUR
T1 - Histological suggestions of 'paratransformation' in oesophageal squamous cell carcinoma
AU - Kuwano, Hiroyuki
AU - Sumiyoshi, Kohei
AU - Yasuda, Mitsuhiro
AU - Nozoe, Tadahiro
AU - Watanabe, Masayuki
AU - Ohno, Shinji
AU - Sugimachi, Keizo
N1 - Funding Information:
This work was supported, in part, by the Grant No. 3986 from the Japanese Ministry of Education and by the Grant of Fukuoka Cancer Society.
PY - 1995/10
Y1 - 1995/10
N2 - We have postulated that oesophageal squamous cell carcinoma arises from multifocal areas and not from one cell, and we present the circumstantial evidence for field carcinogenesis in oesophageal cancer. Among 290 cases examined with oesophageal squamous cell carcinoma, lymphatic permeation or intramural metastasis was evident in 110 cases. Of these carcinomatous transformation of the epithelium adjacent to either lymphatic vessel permeation or intramural metastasis of the squamous cell carcinoma was recognized in six cases. It is considered that the cancer tissue either in the lymphatic vessel or intramural metastasis promotes a malignant transformation of the squamous epithelium over these foci. 'Paratransformation' is therefore thought to be one of the potential models of origin for oesophageal squamous cell carcinoma.
AB - We have postulated that oesophageal squamous cell carcinoma arises from multifocal areas and not from one cell, and we present the circumstantial evidence for field carcinogenesis in oesophageal cancer. Among 290 cases examined with oesophageal squamous cell carcinoma, lymphatic permeation or intramural metastasis was evident in 110 cases. Of these carcinomatous transformation of the epithelium adjacent to either lymphatic vessel permeation or intramural metastasis of the squamous cell carcinoma was recognized in six cases. It is considered that the cancer tissue either in the lymphatic vessel or intramural metastasis promotes a malignant transformation of the squamous epithelium over these foci. 'Paratransformation' is therefore thought to be one of the potential models of origin for oesophageal squamous cell carcinoma.
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U2 - 10.1016/S0748-7983(95)97231-5
DO - 10.1016/S0748-7983(95)97231-5
M3 - Article
C2 - 7589602
AN - SCOPUS:0028847018
VL - 21
SP - 541
EP - 544
JO - European Journal of Surgical Oncology
JF - European Journal of Surgical Oncology
SN - 0748-7983
IS - 5
ER -
