Histone core slips along DNA and prefers positioning at the chain end

Takahiro Sakaue, Kenichi Yoshikawa, Shige H. Yoshimura, Kunio Takeyasu

Research output: Contribution to journalArticlepeer-review

65 Citations (Scopus)

Abstract

We studied the stability and dynamics of a model of a nucleosome, the fundamental unit for the packing of long DNA in eukaryotes, using a Brownian dynamics simulation. For the proper folding of a stiff polymer on a core particle, moderate attractive interaction is shown to be essentially important, which explains the empirical experimental protocol for the reconstitution of nucleosomes. The effect of the chain end on the positioning of the core particle is examined and compared with the experimental data by atomic force microscopy measurement. It is also suggested that the core particle exhibits sliding motion alongthe chain as a manifestation of Brownian motion.

Original languageEnglish
Pages (from-to)78105-1-78105-4
JournalPhysical review letters
Volume87
Issue number7
DOIs
Publication statusPublished - Aug 13 2001

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)

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