Histopathologic findings of minute foci of squamous cell carcinoma in the human esophagus

Hiroyuki Kuwano, Masaru Morita, Hiroyuki Matsuda, Masaki Mori, Keizo Sugimachi

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

To examine the histogenesis and progression of esophageal squamous cell carcinoma, 76 cases of a primary squamous cell carcinoma were reviewed retrospectively, and 16 lesions of squamous cell carcinoma of the esophagus less than 1.0 cm in diameter were studied histopathologically. None of the patients had received radiation therapy preoperatively. Among 16 foci, 13 were intraepithelial carcinomas, and three were restricted to within the mucosa. In two patients with a solitary, minute cancer, there were no associated areas of dysplasia. In 11 patients with multiple primary minute foci, seven contained 14 areas of dysplasia in the esophagus. There was no continuity between the minute foci of carcinoma and areas of dysplasia. These findings are interpreted to mean that dysplasia is a “subcancerous” lesion rather than a “precancerous” one and that various degrees of lesions such as dysplasia and carcinoma occur multicentrically in the same esophagus. The sequence of dysplasia to carcinoma must be examined using the techniques of molecular biology. Cancer 68:2617–2620, 1991.

Original languageEnglish
Pages (from-to)2617-2620
Number of pages4
JournalCancer
Volume68
Issue number12
DOIs
Publication statusPublished - Jan 1 1991

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Esophagus
Squamous Cell Carcinoma
Carcinoma
Carcinoma in Situ
Molecular Biology
Neoplasms
Mucous Membrane
Radiotherapy
Esophageal Squamous Cell Carcinoma

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Histopathologic findings of minute foci of squamous cell carcinoma in the human esophagus. / Kuwano, Hiroyuki; Morita, Masaru; Matsuda, Hiroyuki; Mori, Masaki; Sugimachi, Keizo.

In: Cancer, Vol. 68, No. 12, 01.01.1991, p. 2617-2620.

Research output: Contribution to journalArticle

Kuwano, Hiroyuki ; Morita, Masaru ; Matsuda, Hiroyuki ; Mori, Masaki ; Sugimachi, Keizo. / Histopathologic findings of minute foci of squamous cell carcinoma in the human esophagus. In: Cancer. 1991 ; Vol. 68, No. 12. pp. 2617-2620.
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