Histopathological factors influencing pelvic lymph node metastases in two or more sites in patients with cervical carcinoma undergoing radical hysterectomy

Toshiharu Kamura, Toshiyuki Shigematsu, Tsunehisa Kaku, Tomihiro Shimamoto, Toshiaki Saito, Kunihiro Sakai, Masamune Mitsumoto, Hitoo Nakano

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Background. Lymph node metastasis has been one of the strongest prognostic factors in patients with cervical cancer. In order to select patients with high risk for recurrence, a relationship between status of lymph node and other histopathological parameters was investigated in the patients treated with radical hysterectomy with pelvic lymph adnectomy. Methods. Of 483 patients undergoing radical hysterectomy with pelvic lymph adnectomy, 309 had stage Ib disease, 62 stage IIa, and 112 stage IIb. Results. Pelvic lymph node metastasis (PLNM) was positive in 98 patients (20%). Of those positive patients, 51 (56%) had metastasis in one site, 25 (26%) in two sites, and 22 (22%) in three or more sites. There was a significant difference in survival between patients with metastasis in one or no sites and those in two or more sites (p < 0.0001). There was a relationship between PLNM in more than two sites and histological parameters such as histologic subtype, longitudinal diameter of cervical lesion, degree of stromal invasion, depth of stromal invasion, lymph-vascular space invasion, parametrial invasion, and corpus invasion. All of these parameters except for histologic subtype were significantly correlated with the number of positive lymph node sites. Multivariate analysis revealed that among these parameters, longitudinal diameter of the cervical lesion, parametrial invasion, and lymph-vascular space invasion were independently significantly correlated with PLNM in two or more sites. Conclusions. From these results, patients having these three histopathological parameters could be considered as those with extensive disease distribution.

Original languageEnglish
Pages (from-to)452-457
Number of pages6
JournalActa Obstetricia et Gynecologica Scandinavica
Volume78
Issue number5
Publication statusPublished - May 7 1999

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Hysterectomy
Lymph Nodes
Neoplasm Metastasis
Carcinoma
Lymph
Blood Vessels
Uterine Cervical Neoplasms
Multivariate Analysis
Recurrence
Survival

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology

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Histopathological factors influencing pelvic lymph node metastases in two or more sites in patients with cervical carcinoma undergoing radical hysterectomy. / Kamura, Toshiharu; Shigematsu, Toshiyuki; Kaku, Tsunehisa; Shimamoto, Tomihiro; Saito, Toshiaki; Sakai, Kunihiro; Mitsumoto, Masamune; Nakano, Hitoo.

In: Acta Obstetricia et Gynecologica Scandinavica, Vol. 78, No. 5, 07.05.1999, p. 452-457.

Research output: Contribution to journalArticle

Kamura, T, Shigematsu, T, Kaku, T, Shimamoto, T, Saito, T, Sakai, K, Mitsumoto, M & Nakano, H 1999, 'Histopathological factors influencing pelvic lymph node metastases in two or more sites in patients with cervical carcinoma undergoing radical hysterectomy', Acta Obstetricia et Gynecologica Scandinavica, vol. 78, no. 5, pp. 452-457.
Kamura, Toshiharu ; Shigematsu, Toshiyuki ; Kaku, Tsunehisa ; Shimamoto, Tomihiro ; Saito, Toshiaki ; Sakai, Kunihiro ; Mitsumoto, Masamune ; Nakano, Hitoo. / Histopathological factors influencing pelvic lymph node metastases in two or more sites in patients with cervical carcinoma undergoing radical hysterectomy. In: Acta Obstetricia et Gynecologica Scandinavica. 1999 ; Vol. 78, No. 5. pp. 452-457.
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N2 - Background. Lymph node metastasis has been one of the strongest prognostic factors in patients with cervical cancer. In order to select patients with high risk for recurrence, a relationship between status of lymph node and other histopathological parameters was investigated in the patients treated with radical hysterectomy with pelvic lymph adnectomy. Methods. Of 483 patients undergoing radical hysterectomy with pelvic lymph adnectomy, 309 had stage Ib disease, 62 stage IIa, and 112 stage IIb. Results. Pelvic lymph node metastasis (PLNM) was positive in 98 patients (20%). Of those positive patients, 51 (56%) had metastasis in one site, 25 (26%) in two sites, and 22 (22%) in three or more sites. There was a significant difference in survival between patients with metastasis in one or no sites and those in two or more sites (p < 0.0001). There was a relationship between PLNM in more than two sites and histological parameters such as histologic subtype, longitudinal diameter of cervical lesion, degree of stromal invasion, depth of stromal invasion, lymph-vascular space invasion, parametrial invasion, and corpus invasion. All of these parameters except for histologic subtype were significantly correlated with the number of positive lymph node sites. Multivariate analysis revealed that among these parameters, longitudinal diameter of the cervical lesion, parametrial invasion, and lymph-vascular space invasion were independently significantly correlated with PLNM in two or more sites. Conclusions. From these results, patients having these three histopathological parameters could be considered as those with extensive disease distribution.

AB - Background. Lymph node metastasis has been one of the strongest prognostic factors in patients with cervical cancer. In order to select patients with high risk for recurrence, a relationship between status of lymph node and other histopathological parameters was investigated in the patients treated with radical hysterectomy with pelvic lymph adnectomy. Methods. Of 483 patients undergoing radical hysterectomy with pelvic lymph adnectomy, 309 had stage Ib disease, 62 stage IIa, and 112 stage IIb. Results. Pelvic lymph node metastasis (PLNM) was positive in 98 patients (20%). Of those positive patients, 51 (56%) had metastasis in one site, 25 (26%) in two sites, and 22 (22%) in three or more sites. There was a significant difference in survival between patients with metastasis in one or no sites and those in two or more sites (p < 0.0001). There was a relationship between PLNM in more than two sites and histological parameters such as histologic subtype, longitudinal diameter of cervical lesion, degree of stromal invasion, depth of stromal invasion, lymph-vascular space invasion, parametrial invasion, and corpus invasion. All of these parameters except for histologic subtype were significantly correlated with the number of positive lymph node sites. Multivariate analysis revealed that among these parameters, longitudinal diameter of the cervical lesion, parametrial invasion, and lymph-vascular space invasion were independently significantly correlated with PLNM in two or more sites. Conclusions. From these results, patients having these three histopathological parameters could be considered as those with extensive disease distribution.

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