HLA-A and DPB1 loci confer susceptibility to Grave's disease

Rui Ping Dong, Akinori Kimura, Ryoko Okubo, Hirotoshi Shinagawa, Hajime Tamai, Yasuharu Nishimura, Takehiko Sasazuki

Research output: Contribution to journalArticle

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Abstract

To investigate HLA-linked genetic factors involved in the pathogenesis of Grave's disease, 76 patients and 317 healthy controls in the Japanese population were examined for HLA-A, B, C, DR, and DQ specificities by serologic typing and for HLA-DPB1 alleles by DNA typing by using the PCR-SSOP method. The frequencies of HLA-A2, B46, Cw11, and DPB1*0501 were increased and those of HLA-A24, B7, Bw52, and DR1 were decreased in the patients. The increased frequencies of HLA-A2 and DPB1*0501 in the patients were statistically significant when the corrected value (pc) was applied (pc < 0.02 and pc < 0.002, respectively). ORs for a risk to develop the disease were calculated among individuals positive for DPB1*0501 and/or HLA-A2, and the highest OR (10.5) was observed in individuals possessed both DPB1*0501 and HLA-A2. This observation suggests a synergic involvement of a HLA class II allele (DPB1*0501) and an HLA class I allele (HLA-A2) in the pathogenesis of Grave's disease.

Original languageEnglish
Pages (from-to)165-172
Number of pages8
JournalHuman Immunology
Volume35
Issue number3
DOIs
Publication statusPublished - Jan 1 1992

Fingerprint

HLA-A2 Antigen
HLA-A Antigens
Graves Disease
Alleles
HLA-A24 Antigen
HLA-B7 Antigen
HLA-B Antigens
DNA Fingerprinting
HLA-DPB1 antigen
Polymerase Chain Reaction
Population

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Dong, R. P., Kimura, A., Okubo, R., Shinagawa, H., Tamai, H., Nishimura, Y., & Sasazuki, T. (1992). HLA-A and DPB1 loci confer susceptibility to Grave's disease. Human Immunology, 35(3), 165-172. https://doi.org/10.1016/0198-8859(92)90101-R

HLA-A and DPB1 loci confer susceptibility to Grave's disease. / Dong, Rui Ping; Kimura, Akinori; Okubo, Ryoko; Shinagawa, Hirotoshi; Tamai, Hajime; Nishimura, Yasuharu; Sasazuki, Takehiko.

In: Human Immunology, Vol. 35, No. 3, 01.01.1992, p. 165-172.

Research output: Contribution to journalArticle

Dong, RP, Kimura, A, Okubo, R, Shinagawa, H, Tamai, H, Nishimura, Y & Sasazuki, T 1992, 'HLA-A and DPB1 loci confer susceptibility to Grave's disease', Human Immunology, vol. 35, no. 3, pp. 165-172. https://doi.org/10.1016/0198-8859(92)90101-R
Dong RP, Kimura A, Okubo R, Shinagawa H, Tamai H, Nishimura Y et al. HLA-A and DPB1 loci confer susceptibility to Grave's disease. Human Immunology. 1992 Jan 1;35(3):165-172. https://doi.org/10.1016/0198-8859(92)90101-R
Dong, Rui Ping ; Kimura, Akinori ; Okubo, Ryoko ; Shinagawa, Hirotoshi ; Tamai, Hajime ; Nishimura, Yasuharu ; Sasazuki, Takehiko. / HLA-A and DPB1 loci confer susceptibility to Grave's disease. In: Human Immunology. 1992 ; Vol. 35, No. 3. pp. 165-172.
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