HLA and Acute Poststreptococcal Glomerulonephritis

T. Sasazuki, R. Hayase, I. Iwamoto, H. Tsuchida

Research output: Contribution to journalLetter

9 Citations (Scopus)

Abstract

To the Editor: Immunogenetic factors responsible for the development of acute glomerulonephritis after streptococcal infection have not yet been clarified, although several attempts have been made to elucidate the interactions between hosts and nephritogenic streptococci.1 2 3 However, the strong associations between HLA-D specificities and several diseases that have been demonstrated in recent years4 5 6 suggest that HLA-linked immune-response genes or immunosuppressive genes are important in the pathogenesis of these diseases. We selected 46 Japanese patients with acute poststreptococcal glomerulonephritis and typed their HLA-A, HLA-B, HLA-C, and HLA-D antigens to investigate the immunogenetic factors governing susceptibility to this disease. As shown in Table 1,. No extract is available for articles shorter than 400 words.

Original languageEnglish
Pages (from-to)1184-1185
Number of pages2
JournalNew England Journal of Medicine
Volume301
Issue number21
DOIs
Publication statusPublished - Nov 22 1979
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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    Sasazuki, T., Hayase, R., Iwamoto, I., & Tsuchida, H. (1979). HLA and Acute Poststreptococcal Glomerulonephritis. New England Journal of Medicine, 301(21), 1184-1185. https://doi.org/10.1056/NEJM197911223012117