HLA and Acute Poststreptococcal Glomerulonephritis

Takehiko Sasazuki, R. Hayase, I. Iwamoto, H. Tsuchida

Research output: Contribution to journalLetter

10 Citations (Scopus)

Abstract

To the Editor: Immunogenetic factors responsible for the development of acute glomerulonephritis after streptococcal infection have not yet been clarified, although several attempts have been made to elucidate the interactions between hosts and nephritogenic streptococci.1 2 3 However, the strong associations between HLA-D specificities and several diseases that have been demonstrated in recent years4 5 6 suggest that HLA-linked immune-response genes or immunosuppressive genes are important in the pathogenesis of these diseases. We selected 46 Japanese patients with acute poststreptococcal glomerulonephritis and typed their HLA-A, HLA-B, HLA-C, and HLA-D antigens to investigate the immunogenetic factors governing susceptibility to this disease. As shown in Table 1,. No extract is available for articles shorter than 400 words.

Original languageEnglish
Pages (from-to)1184-1185
Number of pages2
JournalNew England Journal of Medicine
Volume301
Issue number21
DOIs
Publication statusPublished - Nov 22 1979
Externally publishedYes

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HLA-D Antigens
Immunogenetics
Glomerulonephritis
HLA-C Antigens
Streptococcal Infections
HLA-A Antigens
HLA-B Antigens
Disease Susceptibility
Immunosuppressive Agents
Genes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Sasazuki, T., Hayase, R., Iwamoto, I., & Tsuchida, H. (1979). HLA and Acute Poststreptococcal Glomerulonephritis. New England Journal of Medicine, 301(21), 1184-1185. https://doi.org/10.1056/NEJM197911223012117

HLA and Acute Poststreptococcal Glomerulonephritis. / Sasazuki, Takehiko; Hayase, R.; Iwamoto, I.; Tsuchida, H.

In: New England Journal of Medicine, Vol. 301, No. 21, 22.11.1979, p. 1184-1185.

Research output: Contribution to journalLetter

Sasazuki, T, Hayase, R, Iwamoto, I & Tsuchida, H 1979, 'HLA and Acute Poststreptococcal Glomerulonephritis', New England Journal of Medicine, vol. 301, no. 21, pp. 1184-1185. https://doi.org/10.1056/NEJM197911223012117
Sasazuki, Takehiko ; Hayase, R. ; Iwamoto, I. ; Tsuchida, H. / HLA and Acute Poststreptococcal Glomerulonephritis. In: New England Journal of Medicine. 1979 ; Vol. 301, No. 21. pp. 1184-1185.
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AB - To the Editor: Immunogenetic factors responsible for the development of acute glomerulonephritis after streptococcal infection have not yet been clarified, although several attempts have been made to elucidate the interactions between hosts and nephritogenic streptococci.1 2 3 However, the strong associations between HLA-D specificities and several diseases that have been demonstrated in recent years4 5 6 suggest that HLA-linked immune-response genes or immunosuppressive genes are important in the pathogenesis of these diseases. We selected 46 Japanese patients with acute poststreptococcal glomerulonephritis and typed their HLA-A, HLA-B, HLA-C, and HLA-D antigens to investigate the immunogenetic factors governing susceptibility to this disease. As shown in Table 1,. No extract is available for articles shorter than 400 words.

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