Hla And Clinical Manifestations In Takayasu Disease

Fujio Numano, Nobuo Ohta, Takehiko Sasazuki

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

In previous studies on HLA antigens in patients with Takayasu disease, we found a statistically high frequency of haplotype Bw52-Dw l2. Clinicopathological conditions of this disease observed for 85 ± 3 months were compared between 29 patients with (positive group) and 39 patients without this haplotype (negative group), among 82 patients with Takayasu disease. Blood sedimentation rate and C-reactive protein exhibited statistically significant high figures in the positive group as compared with those in negative group, while no differences were seen in rheumatoid arthritis test, antistreptolysin-0 titer, anti-DNA antibody, levels of circulating immune complexes, platelet aggregation, although all revealed high levels in the positive group. Pulmonary disorders were more frequent in positive group. Fourteen patients (48%) in the positive group and 5 (13%) in the negative group had abnormalities in the aortic valve (p < 0.01). In 14 patients in the positive (38%) and 5 in the negative (13%) groups, the systolic blood pressure was over 140 mmHg (p<0.01). Four patients in the positive (17%) and one in the negative groups (3%) were blind (p < 0.01). These data suggest that in patients with a haplotype of Bw52-Dwl2, there is a greater likelihood of an active inflammatory state and a rapid progression of these morbid conditions.

Original languageEnglish
Pages (from-to)184-189
Number of pages6
JournalJAPANESE CIRCULATION JOURNAL
Volume46
Issue number2
DOIs
Publication statusPublished - Jan 1982

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Takayasu Arteritis
Haplotypes
Antistreptolysin
Blood Pressure
Antinuclear Antibodies
Blood Sedimentation
HLA Antigens
Antigen-Antibody Complex
Aortic Valve
Platelet Aggregation
C-Reactive Protein
Rheumatoid Arthritis
Lung

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Hla And Clinical Manifestations In Takayasu Disease. / Numano, Fujio; Ohta, Nobuo; Sasazuki, Takehiko.

In: JAPANESE CIRCULATION JOURNAL, Vol. 46, No. 2, 01.1982, p. 184-189.

Research output: Contribution to journalArticle

Numano, Fujio ; Ohta, Nobuo ; Sasazuki, Takehiko. / Hla And Clinical Manifestations In Takayasu Disease. In: JAPANESE CIRCULATION JOURNAL. 1982 ; Vol. 46, No. 2. pp. 184-189.
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