HLA antigens in japanese patients with systemic lupus erythematosus

H. Hashimoto, Y. Nishimura, R. P. Dong, A. Kimura, Takehiko Sasazuki, K. Yamanaka, Y. Tokano, A. Murashima, K. Kabasawa, S. Hirose

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

To determine the association of HLA antigens with SLE and the clinical findings of the disease, HLA antigens were tested in 58 Japanese patients with SLE, who fulfilled the ARA diagnostic criteria, along with 97 normal controls. HLA class I and II antigens were typed serologically using the antisera provided by the 11th HLA Workshop. Among the HLA class II antigens, further DRB, DQ and DP alleles were defined by DNA typing using the PCR/SSOP method. There were significantly more SLE patients with HLA-B39, DRB1*1501, DRB5*0101 and DQB1*0602 than normal controls. This result suggested that the haplotype of HLA-DRB1*1501-DRB5*0101-DQA1*0102-DQB1*0602 consists of the SLE-associated MHC markers in Japan. There were some positive and negative associations between the HLA antigens and clinical or serological findings in SLE. There is a possibility that some HLA alleles might be related to the clinical and/or serological subsets of SLE.

Original languageEnglish
Pages (from-to)191-196
Number of pages6
JournalScandinavian Journal of Rheumatology
Volume23
Issue number4
DOIs
Publication statusPublished - Jan 1 1994

Fingerprint

HLA Antigens
Systemic Lupus Erythematosus
HLA-DRB1 Chains
Histocompatibility Antigens Class II
HLA-B39 Antigen
Alleles
Dichlororibofuranosylbenzimidazole
Histocompatibility Antigens Class I
DNA Fingerprinting
Haplotypes
Immune Sera
Japan
Education
Polymerase Chain Reaction
HLA-DQB1 antigen

All Science Journal Classification (ASJC) codes

  • Rheumatology
  • Immunology and Allergy
  • Immunology

Cite this

Hashimoto, H., Nishimura, Y., Dong, R. P., Kimura, A., Sasazuki, T., Yamanaka, K., ... Hirose, S. (1994). HLA antigens in japanese patients with systemic lupus erythematosus. Scandinavian Journal of Rheumatology, 23(4), 191-196. https://doi.org/10.3109/03009749409103059

HLA antigens in japanese patients with systemic lupus erythematosus. / Hashimoto, H.; Nishimura, Y.; Dong, R. P.; Kimura, A.; Sasazuki, Takehiko; Yamanaka, K.; Tokano, Y.; Murashima, A.; Kabasawa, K.; Hirose, S.

In: Scandinavian Journal of Rheumatology, Vol. 23, No. 4, 01.01.1994, p. 191-196.

Research output: Contribution to journalArticle

Hashimoto, H, Nishimura, Y, Dong, RP, Kimura, A, Sasazuki, T, Yamanaka, K, Tokano, Y, Murashima, A, Kabasawa, K & Hirose, S 1994, 'HLA antigens in japanese patients with systemic lupus erythematosus', Scandinavian Journal of Rheumatology, vol. 23, no. 4, pp. 191-196. https://doi.org/10.3109/03009749409103059
Hashimoto H, Nishimura Y, Dong RP, Kimura A, Sasazuki T, Yamanaka K et al. HLA antigens in japanese patients with systemic lupus erythematosus. Scandinavian Journal of Rheumatology. 1994 Jan 1;23(4):191-196. https://doi.org/10.3109/03009749409103059
Hashimoto, H. ; Nishimura, Y. ; Dong, R. P. ; Kimura, A. ; Sasazuki, Takehiko ; Yamanaka, K. ; Tokano, Y. ; Murashima, A. ; Kabasawa, K. ; Hirose, S. / HLA antigens in japanese patients with systemic lupus erythematosus. In: Scandinavian Journal of Rheumatology. 1994 ; Vol. 23, No. 4. pp. 191-196.
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